Gene Report

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Basic Info

Approved Symbol	CHRNA10
Approved Name	cholinergic receptor, nicotinic, alpha 10 (neuronal)
Previous Name	cholinergic receptor, nicotinic, alpha polypeptide 10
Name Alias	acetylcholine receptor, nicotinic, alpha 10 (neuronal)
Location	11p15.5
Position	chr11:3665587-3671384, -1
External Links	HGNC: 13800 Entrez Gene: 57053 Ensembl: ENSG00000129749 UCSC: uc001lyf.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Shi, J., 2007	SNP: rs2271583, rs2672213, rs2741862, rs6578411, rs7123164	no evidence of interaction among these 19 cholinergic genes was found by Allelic Association, Haploview Tests, FITF analysis and FDR correction	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045211	postsynaptic membrane	cellular component	IEA	68
GO:0016020	membrane	cellular component	TAS[11350119]	137
GO:0005102	receptor binding	molecular function	TAS[11350119]	37
GO:0005262	calcium channel activity	molecular function	IEA	9

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	biological process	IEA	2
GO:0005892	acetylcholine-gated channel complex	cellular component	IEA	13
GO:0042127	regulation of cell proliferation	biological process	TAS[11350119]	14
GO:0007271	synaptic transmission, cholinergic	biological process	TAS[11350119]	14
GO:0004889	acetylcholine-activated cation-selective channel activity	molecular function	IEA	13
GO:0030424	axon	cellular component	IEA	39
GO:0007204	positive regulation of cytosolic calcium ion concentration	biological process	IGI[18420419]	21
GO:0043204	perikaryon	cellular component	IEA	17
GO:0042472	inner ear morphogenesis	biological process	IEA	8
GO:0070588	calcium ion transmembrane transport	biological process	IEA	24
GO:0030054	cell junction	cellular component	IEA	88

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 6)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs7123164	chr11:3657216 - 3657216(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs2271583	chr11:3664425 - 3664425(1)	downstream_gene_variant; upstream_gene_variant	1(0/1/0)
rs2672213	chr11:3670187 - 3670187(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant	1(0/1/0)
rs2741862	chr11:3666755 - 3666755(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant	1(0/1/0)
rs6578411	chr11:3674742 - 3674742(1)	downstream_gene_variant; intron_variant; upstream_gene_variant	1(0/1/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs2231529		chr11:3672023 - 3672023(1)	downstream_gene_variant; intron_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 11	chr11:0-135086622	2 (0/2/0)
11p15	chr11:0-22000000	5 (0/4/1)
11p15.4	chr11:2800000-11700000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr11:3665587..3671384 View in gBrowse