Gene Report

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Basic Info

Approved Symbol	SLIT3
Previous Symbol	SLIL2
Symbol Alias	slit2, MEGF5, SLIT1, Slit-3
Approved Name	slit homolog 3 (Drosophila)
Previous Name	slit (Drosophila) homolog 3
Location	5q35
Position	chr5:168661733-169301129, -1
External Links	HGNC: 11087 Entrez Gene: 6586 Ensembl: ENSG00000184347 UCSC: uc010jjg.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0011. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005509	calcium ion binding	molecular function	NAS[9813312]	50
GO:0007411	axon guidance	biological process	IDA[11748139]; TAS	60

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0032870	cellular response to hormone stimulus	biological process	IEP[18566128]	9
GO:0021834	chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration	biological process	IDA[11748139]	1
GO:0030308	negative regulation of cell growth	biological process	IMP[18829537]	11
GO:0010629	negative regulation of gene expression	biological process	IEA	12
GO:0048846	axon extension involved in axon guidance	biological process	IDA[16840550]	1
GO:0005615	extracellular space	cellular component	IDA[19741192]	85
GO:0070100	negative regulation of chemokine-mediated signaling pathway	biological process	IMP[18829537]	1
GO:0050919	negative chemotaxis	biological process	IDA[11748139]	1
GO:0008285	negative regulation of cell proliferation	biological process	IEA	41
GO:0035385	Roundabout signaling pathway	biological process	IMP[18829537]	1
GO:0048495	Roundabout binding	molecular function	IPI[15207848]	1
GO:0051414	response to cortisol	biological process	IEP[18566128]	2
GO:0009887	organ morphogenesis	biological process	IEA	9
GO:0005739	mitochondrion	cellular component	NAS[11443047]	75
GO:0061364	apoptotic process involved in luteolysis	biological process	IEP[18566128]	2

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04360	Axon guidance	16

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
SLIT3	ROBO2	YES	in vitro;in vivo	11754167
SLIT3	CAPN1	NO	yeast 2-hybrid	12358155

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 5	chr5:0-181538259	3 (0/2/1)
5q35.1	chr5:168500000-172800000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	ID in SZGene	Result Category
15231749	346	Positive

Gene relationship with MDD

Reference	Description	Category in MDD	Link in MK4MDD
21152026	The most significant locus was observed on 5q35.1, harboring the SLIT3 gene (P = 2x10(-3))	Pos	SLIT3

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Region: chr5:168661733..169301129 View in gBrowse