Gene Report

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Basic Info

Approved Symbol	TRHR
Approved Name	thyrotropin-releasing hormone receptor
Location	8q23.1
Position	chr8:109086621-109119584, 1
External Links	HGNC: 12299 Entrez Gene: 7201 Ensembl: ENSG00000174417 UCSC: uc003ymz.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs2980619, rs4129682, rs4734194, rs6469241	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0005887	integral component of plasma membrane	cellular component	TAS[8395824]	158

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004997	thyrotropin-releasing hormone receptor activity	molecular function	IEA	1
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IEA	64

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04020	Calcium signaling pathway	53

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TRHR	ARRB1	NO	in vitro	12393857 , 11278883
TRHR	TRH	YES	in vitro;in vivo	15117874 , 9794253

Related other genetic factors

Gene related SNPs (count: 12)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2980619	chr8:109289818 - 109289818(1)	3_prime_UTR_variant; missense_variant; NMD_transcript_variant	1(0/1/0)
rs4734194	chr8:109138442 - 109138442(1)		1(0/1/0)
rs4129682	chr8:109109910 - 109109910(1)	intron_variant	1(0/1/0)
rs6469241	chr8:109141703 - 109141703(1)		1(0/1/0)

rs_ID	Location	Functional Annotation
rs11778370	chr8:109113377 - 109113377(1)	intron_variant
rs4301422	chr8:109113949 - 109113949(1)	intron_variant
rs4735093	chr8:109102110 - 109102110(1)	intron_variant
rs4735094	chr8:109111764 - 109111764(1)	intron_variant
rs10955505	chr8:109122209 - 109122209(1)	downstream_gene_variant
rs4342559	chr8:109114056 - 109114056(1)	intron_variant
rs10505126	chr8:109122051 - 109122051(1)	downstream_gene_variant
rs4735092	chr8:109102046 - 109102046(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 8	chr8:0-145138636	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr8:109086621..109119584 View in gBrowse