Gene Report

Basic Info
Approved Symbol EGR2
Previous Symbol KROX20
Approved Name early growth response 2
Previous Name early growth response 2 (Krox-20 homolog, Drosophila)
Name Alias Krox-20 homolog, Drosophila
Location 10q21.1
Position chr10:62811996-62919900, -1
External Links HGNC: 3239
Entrez Gene: 1959
Ensembl: ENSG00000122877
UCSC: uc001jmi.3
No. of Studies 3 (Positive: 1; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Balan S, 2013 SNP: rs2297489, rs2297488, rs61865882, rs2295814 The results fail to support the role of EGR2 in the pathogenesis of bipolar disorder in the Japanese population. Negative Comment on Study
Kim, S. H.,2011 SNP: rs10995315, rs1509963, rs224278, rs2295814, rs2297488, rs2297489, rs45602133, rs61865882, rs9990
Haplotype: rs10995315 - rs2297488 - rs2297489 - rs224278(A-A-G-C), rs10995315 - rs2297488 - rs2297489 - rs224278(G-G-C-C), rs10995315 - rs2297488 - rs2297489 - rs224278(G-G-C-T), rs9990 - rs1509963 - rs2295814 - rs61865882 - rs45602133(C-G-G-T-T), rs9990 - rs1509963 - rs2295814 - rs61865882 - rs45602133(T-A-G-T-G), rs9990 - rs1509963 - rs2295814 - rs61865882 - rs45602133(T-A-G-T-T), rs9990 - rs1509963 - rs2295814 - rs61865882 - rs45602133(T-G-A-C-T)
Although an extended analysis with a larger sample size or independent replication is required, these findings suggest a genetic association of EGR2 with BD. Combined with a plausible biological function of EGR2, the EGR2 gene is a possible susceptibility gene in BD. Positive Comment on Study
Gallitano, A. L.,2012 SNP: rs10128333, rs1509963, rs2295814, rs2297488 None of the SNPs tested in EGR2 was associated with child BP-I. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 37)

GO terms by PBA (count: 4)

GO terms by database search (count: 33)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Related other genetic factors
Gene related SNPs (count: 34)

Literature-origin SNPs (count: 10)

LD-proxies (count: 24)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 4)

Gene relationship with MDD

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Region: chr10:62811996..62919900 View in gBrowse
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