Gene Report

Approved Symbol	EGR2
Previous Symbol	KROX20
Approved Name	early growth response 2
Previous Name	early growth response 2 (Krox-20 homolog, Drosophila)
Name Alias	Krox-20 homolog, Drosophila
Location	10q21.1
Position	chr10:62811996-62919900, -1
External Links	HGNC: 3239 Entrez Gene: 1959 Ensembl: ENSG00000122877 UCSC: uc001jmi.3
No. of Studies	3 (Positive: 1; Negative: 2; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Balan S, 2013	SNP: rs2297489, rs2297488, rs61865882, rs2295814	The results fail to support the role of EGR2 in the pathogenesis of bipolar disorder in the Japanese population.	Negative	Comment on Study
Kim, S. H.,2011	SNP: rs10995315, rs1509963, rs224278, rs2295814, rs2297488, rs2297489, rs45602133, rs61865882, rs9990 Haplotype: rs10995315 - rs2297488 - rs2297489 - rs224278(A-A-G-C), rs10995315 - rs2297488 - rs2297489 - rs224278(G-G-C-C), rs10995315 - rs2297488 - rs2297489 - rs224278(G-G-C-T), rs9990 - rs1509963 - rs2295814 - rs61865882 - rs45602133(C-G-G-T-T), rs9990 - rs1509963 - rs2295814 - rs61865882 - rs45602133(T-A-G-T-G), rs9990 - rs1509963 - rs2295814 - rs61865882 - rs45602133(T-A-G-T-T), rs9990 - rs1509963 - rs2295814 - rs61865882 - rs45602133(T-G-A-C-T)	Although an extended analysis with a larger sample size or independent replication is required, these findings suggest a genetic association of EGR2 with BD. Combined with a plausible biological function of EGR2, the EGR2 gene is a possible susceptibility gene in BD.	Positive	Comment on Study
Gallitano, A. L.,2012	SNP: rs10128333, rs1509963, rs2295814, rs2297488	None of the SNPs tested in EGR2 was associated with child BP-I.	Negative	Comment on Study

Region: chr10:62811996..62919900 View in gBrowse