Gene Report

Basic Info
Approved Symbol MPPE1
Approved Name metallophosphoesterase 1
Location 18p11.21
Position chr18:11882622-11909223, -1
External Links HGNC: 15988
Entrez Gene: 65258
Ensembl: ENSG00000154889
UCSC: uc002kqf.4
No. of Studies 2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Yosifova, A.,2009 SNP: rs3974590, rs662515, rs673735, rs8097892 Significant association of SNP in this gene with BD in our population was observed. Positive Comment on Study
Lohoff, F. W., 2010 SNP: rs3974590, rs593713, rs602201, rs871044
Haplotype: rs3974590 - rs593713(GA), rs3974590 - rs593713(AG), rs3974590 - rs593713(GG), rs3974590 - rs593713(AA), rs871044 - rs3974590 - rs593713 - rs602201(GGAT), rs871044 - rs3974590 - rs593713 - rs602201(AGAT), rs871044 - rs3974590 - rs593713 - rs602201(GGAA), rs871044 - rs3974590 - rs593713 - rs602201(GAGA), rs871044 - rs3974590 - rs593713 - rs602201(AAGT), rs871044 - rs3974590 - rs593713 - rs602201(AAGA), rs871044 - rs3974590 - rs593713 - rs602201(AGAA), rs871044 - rs3974590 - rs593713 - rs602201(GAGT), rs871044 - rs3974590 - rs593713 - rs602201(GAAT)
Our results provide evidence of an association between a polymorphism in the MPPE1 gene and BPD. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 13)

GO terms by PBA (count: 1)

GO terms by database search (count: 12)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 9)

Literature-origin SNPs (count: 7)

LD-proxies (count: 2)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr18:11882622..11909223 View in gBrowse
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