Gene Report

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Basic Info

Approved Symbol	MMP3
Previous Symbol	STMY1, STMY
Approved Name	matrix metallopeptidase 3
Previous Name	matrix metalloproteinase 3 (stromelysin 1, progelatinase), "stromelysin 1"
Location	11q22.3
Position	chr11:102835801-102843803, -1
External Links	HGNC: 7173 Entrez Gene: 4314 Ensembl: ENSG00000149968 UCSC: uc001phj.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Kucukali, C. I.,2009	Other variant: MMP3_1171_5A/6A	No significant differences were found in the allele or genotype distribution in patients with BD-I compared with controls.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004222	metalloendopeptidase activity	molecular function	IEA	8
GO:0005509	calcium ion binding	molecular function	IEA	50

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005578	proteinaceous extracellular matrix	cellular component	IEA	19
GO:1903209	positive regulation of oxidative stress-induced cell death	biological process	ISS	1
GO:0030198	extracellular matrix organization	biological process	TAS	26
GO:0071230	cellular response to amino acid stimulus	biological process	IEA	6
GO:0006508	proteolysis	biological process	IDA[12867428]	34
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0051898	negative regulation of protein kinase B signaling	biological process	IEA	6
GO:0005576	extracellular region	cellular component	TAS	97
GO:0071732	cellular response to nitric oxide	biological process	TAS[15863497]	1
GO:0022617	extracellular matrix disassembly	biological process	TAS	10
GO:0032461	positive regulation of protein oligomerization	biological process	IDA[19022250]	2
GO:0004175	endopeptidase activity	molecular function	IDA[15863497]	8
GO:0005615	extracellular space	cellular component	TAS[3360803]	85
GO:0030163	protein catabolic process	biological process	IEA	5
GO:0005739	mitochondrion	cellular component	IEA	75
GO:0010727	negative regulation of hydrogen peroxide metabolic process	biological process	IDA[20969476]	1
GO:0030334	regulation of cell migration	biological process	IEA	9
GO:0005829	cytosol	cellular component	IEA	223
GO:0030574	collagen catabolic process	biological process	TAS	4
GO:0008270	zinc ion binding	molecular function	IEA	77

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 16)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
MMP3	PLG	NO	in vitro	9548733
MMP3	SERPINE1	NO	in vitro	10967118
MMP3	TIMP3	NO	in vitro;in vivo	11827795
MMP3	CCL8	NO	in vitro	12149192
MMP3	SPOCK3	NO	in vivo	11751414
MMP3	SPP1	NO	in vitro	11375993
MMP3	SPOCK1	NO	in vitro	12810672
MMP3	TIMP1	NO	in vitro	9288970 , 12834347
MMP3	CCL7	NO	in vitro;in vivo	12149192 , 10947989
MMP3	CCL2	YES	in vitro;in vivo	12149192 , 9558113
MMP3	IGFBP3	NO	in vitro	7523391
MMP3	CCL13	NO	in vitro	12149192
MMP3	HAPLN1	NO	in vitro	7694569
MMP3	BCAN	NO	in vitro	10986281
MMP3	TNFSF11	NO	in vitro	15894268
MMP3	DCN	NO	in vitro	9148753

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
MMP3_1171_5A/6A	insertion/deletion		1 (0/1/0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 11	chr11:0-135086622	2 (0/2/0)
11q22-q23	chr11:97200000-121200000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19245826	In conclusion, our data have supported the hypothesis that there is a possible relationship between ?1171 5A/6A polymorphism of MMP3 gene and SZ.	Positive

Reference	ID in SZGene	Result Category
19245826	765	Positive

Gene relationship with MDD

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Region: chr11:102835801..102843803 View in gBrowse