Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	BDKRB2
Symbol Alias	BK-2
Approved Name	bradykinin receptor B2
Location	14q32.1-q32.2
Position	chr14:96204679-96244166, 1
External Links	HGNC: 1030 Entrez Gene: 624 Ensembl: ENSG00000168398 UCSC: uc010avm.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gratacos, M.,2009	SNP: rs945032	In summary, we have identified a functional variant in the BDKRB2 gene strongly associated (odd ratios between 1.65 and 3.06) to several psychiatric disorders, mainly panic disorder, substance abuse and bipolar disorder.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 25)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IDA[17077303]; TAS	360
GO:0005887	integral component of plasma membrane	cellular component	TAS[7916737]	158
GO:0006954	inflammatory response	biological process	IC[17077303]	23

GO terms by database search (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0043114	regulation of vascular permeability	biological process	IC[17077303]	2
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	biological process	TAS[10653985]	16
GO:0033137	negative regulation of peptidyl-serine phosphorylation	biological process	IEA	3
GO:0005768	endosome	cellular component	IDA[17077303]	27
GO:0019229	regulation of vasoconstriction	biological process	IC[17077303]	10
GO:0007204	positive regulation of cytosolic calcium ion concentration	biological process	TAS[10653985]	21
GO:0031702	type 1 angiotensin receptor binding	molecular function	IPI[10993080]	3
GO:0004435	phosphatidylinositol phospholipase C activity	molecular function	TAS[8302267]	8
GO:0042311	vasodilation	biological process	IEA	6
GO:0042310	vasoconstriction	biological process	IEA	5
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IEA	64
GO:0008015	blood circulation	biological process	NAS[7835885]	6
GO:0008152	metabolic process	biological process	TAS[8302267]	50
GO:0009651	response to salt stress	biological process	IEA	4
GO:0005515	protein binding	molecular function	IPI[18672896]	563
GO:0002020	protease binding	molecular function	IPI[17077303]	10
GO:1902239	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator	biological process	IEA	1
GO:0004947	bradykinin receptor activity	molecular function	IDA[17077303]	2
GO:0046982	protein heterodimerization activity	molecular function	IPI[10993080]	42
GO:0007166	cell surface receptor signaling pathway	biological process	TAS[7916737]	23
GO:0006939	smooth muscle contraction	biological process	IC[17077303]	7
GO:0050482	arachidonic acid secretion	biological process	IDA[17077303]	8

Gene related KEGG pathways (count: 4)

KEGG pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04020	Calcium signaling pathway	53

KEGG pathways by database search (count: 3)

ID	Name	No. of Genes in BDgene
hsa04080	Neuroactive ligand-receptor interaction	92
hsa04610	Complement and coagulation cascades	3
hsa04810	Regulation of actin cytoskeleton	24

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
no1Pathway	Actions of Nitric Oxide in the Heart	9

Gene related interactors from protein-protein interactions data in HPRD (count: 11)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
BDKRB2	PTPN11	NO	in vivo	12177051
BDKRB2	NOS3	YES	in vitro	10681501 , 10510297
BDKRB2	GRK6	NO	in vitro;in vivo	11517230
BDKRB2	PRKCD	NO	in vitro;in vivo	11517230
BDKRB2	GNA11	NO	in vitro;in vivo	12130679
BDKRB2	GRK5	NO	in vitro;in vivo	11517230
BDKRB2	AGTR1	YES	in vivo	10993080
BDKRB2	ADRBK2	YES	in vitro;in vivo	11517230
BDKRB2	ACE	YES	in vivo	10748135
BDKRB2	ADRBK1	NO	in vitro;in vivo	11517230
BDKRB2	GRK4	NO	in vitro;in vivo	11517230

Related other genetic factors

Gene related SNPs (count: 4)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs945032	chr14:96204324 - 96204324(1)	upstream_gene_variant	1(1/0/0)

LD-proxies (count: 3)

rs_ID	Location	Functional Annotation
rs5224	chr14:96241120 - 96241120(1)	intron_variant; synonymous_variant; upstream_gene_variant
rs2069588	chr14:96242330 - 96242330(1)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs2069600	chr14:96246692 - 96246692(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q32	chr14:89300000-107043718	1 (0/1/0)
Chr 14	chr14:0-107043718	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr14:96204679..96244166 View in gBrowse