Gene Report

Approved Symbol	DTNBP1
Symbol Alias	Dysbindin, My031, HPS7, DBND, BLOC1S8
Approved Name	dystrobrevin binding protein 1
Name Alias	dysbindin-1, "biogenesis of lysosomal organelles complex-1, subunit 8"
Location	6p22.3
Position	chr6:15522801-15663058, -1
External Links	HGNC: 17328 Entrez Gene: 84062 Ensembl: ENSG00000047579 UCSC: uc003nbm.3
No. of Studies	8 (Positive: 4; Negative: 3; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	YES

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Yosifova, A.,2009	SNP: rs760761	No SNP of this gene had significant association with BD in our population.	Negative	Comment on Study
Gaysina, D.,2009	SNP: rs1011313, rs16876571, rs17470454, rs2619522, rs2619539, rs2743852, rs3213207, rs760761 Haplotype: rs1011313 - rs760761 - rs2743852(), rs16876571 - rs2619539 - rs3213207(), rs16876571 - rs2619539 - rs3213207 - rs760761(), rs17470454 - rs16876571 - rs2619539(), rs2619539 - rs3213207 - rs1011313(), rs3213207 - rs1011313 - rs760761()	In conclusion, our results are consistent with previous studies in term of a general association between the DTNBP1 and bipolar disorder.	Positive	Comment on Study
Perlis, 2008	SNP: rs1000117, rs1011313, rs1997679, rs760666, rs9296983	permuted P> .005 in gene-based association tests.	Negative	Comment on Study
Breen, G., 2006	SNP: rs1011313, rs1018381, rs2005976, rs2619522, rs2619528, rs2619539, rs3213207, rs760666, rs760761, rs909706 Haplotype: rs2619522 - rs760761 - rs2005976(T-C-G), rs2619522 - rs760761 - rs2005976(G-T-A), rs2619522 - rs760761 - rs2005976 - rs2619528(T-C-G-G), rs2619522 - rs760761 - rs2005976 - rs2619528(G-T-A-A), rs2619522 - rs760761 - rs2619528(T-C-G), rs2619522 - rs760761 - rs2619528(G-T-A), rs760761 - rs2005976 - rs2619528(C-G-G), rs760761 - rs2005976 - rs2619528(T-A-A)	Two polymorphisms showed individual genotypic association with bipolar I disorder. Multiple marker haplotypes were more strongly associated, with the rarer of the two common haplotypes being overrepresented in the patients with bipolar affective disorder.	Positive	Comment on Study
Raybould, R.,2005	SNP: rs2619538, rs2619539, rs3213207 Haplotype: rs2619539 - rs3213207 - rs2619538()	Our data suggest that variation at the polymorphisms examined does not make a major contribution to susceptibility to bipolar disorder in general. They are consistent with the possibility that DTNBP1 influences susceptibility to a subset of bipolar disorder cases with psychosis.	Negative	Comment on Study
Fallin, M. D.,2005		16 SNP typed, Median D'=1, Median r<sup>2</sup> =0.05, 4 LD blocks, 0.59 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in SZ/SZA and BP.. This gene is suggestive to BP and SZ/SZA.	Trend	Comment on Study
Pae, C. U., 2007 (a)	SNP: rs1011313, rs2005976, rs2619522, rs3213207, rs760761 Haplotype: rs3213207 - rs1011313 - rs2005976 - rs760761 - rs2619522(A-C-G-C-A), rs3213207 - rs1011313 - rs2005976 - rs760761 - rs2619522(A-T-G-C-A), rs3213207 - rs1011313 - rs2005976 - rs760761 - rs2619522(A-C-A-T-C), rs3213207 - rs1011313 - rs2005976 - rs760761 - rs2619522(A-C-A-C-A), rs3213207 - rs1011313 - rs2005976 - rs760761 - rs2619522(A-C-G-T-A), rs3213207 - rs1011313 - rs2005976 - rs760761 - rs2619522(A-C-A-C-C), rs3213207 - rs1011313 - rs2005976 - rs760761 - rs2619522(A-C-G-T-C), rs3213207 - rs1011313 - rs2005976 - rs760761 - rs2619522(G-C-A-T-C), rs3213207 - rs1011313 - rs2005976 - rs760761 - rs2619522(A-C-G-C-C), rs3213207 - rs1011313 - rs2005976 - rs760761 - rs2619522(A-T-A-C-A), rs3213207 - rs1011313 - rs2005976 - rs760761 - rs2619522(A-T-G-T-A), rs3213207 - rs1011313 - rs2005976 - rs760761 - rs2619522(A-C-A-T-A), rs3213207 - rs1011313 - rs2005976 - rs760761 - rs2619522(G-C-A-C-C), rs3213207 - rs1011313 - rs2005976 - rs760761 - rs2619522(G-C-G-T-C), rs3213207 - rs1011313 - rs2005976 - rs760761 - rs2619522(A-T-G-C-C), rs3213207 - rs1011313 - rs2005976 - rs760761 - rs2619522(G-T-A-C-C), rs3213207 - rs1011313 - rs2005976 - rs760761 - rs2619522(G-C-G-C-C), rs3213207 - rs1011313 - rs2005976 - rs760761 - rs2619522(G-C-A-T-A), rs3213207 - rs1011313 - rs2005976 - rs760761 - rs2619522(G-T-G-C-A), rs3213207 - rs1011313 - rs2005976 - rs760761 - rs2619522(A-T-A-C-C)	The study suggests that putative variations at DTNBP1 act against susceptibility to BID	Positive	Comment on Study
Joo, E. J., 2007	SNP: rs2619522, rs2619538, rs760761 Haplotype: rs2619522 - rs760761(), rs2619538 - rs2619522(), rs2619538 - rs2619522 - rs760761()	The results suggest that DTNBP1 may contribute more to bipolar I disorder than bipolar II disorder or schizoaffective disorder	Positive	Comment on Study

Region: chr6:15522801..15663058 View in gBrowse