Gene Report

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Basic Info

Approved Symbol	ZNF74
Symbol Alias	Cos52, Zfp520, ZNF520
Approved Name	zinc finger protein 74
Previous Name	zinc finger protein 74 (Cos52)
Location	22q11.2
Position	chr22:20394115-20408461, 1
External Links	HGNC: 13144 Entrez Gene: 7625 Ensembl: ENSG00000185252 UCSC: uc010gsm.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fallin, M. D.,2005		3 SNP typed, Median D'=0.96, Median r<sup>2</sup> =0.46, 1 LD blocks, 0.51 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003677	DNA binding	molecular function	IEA	83
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IBA	66
GO:0007275	multicellular organismal development	biological process	TAS[1639391]	24

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006355	regulation of transcription, DNA-templated	biological process	IBA	62
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0003723	RNA binding	molecular function	IEA	14
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0015629	actin cytoskeleton	cellular component	IDA	18

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ZNF74	POLR2A	YES	in vitro;in vivo	9346935 , 11313019
ZNF74	TRIM28	NO	in vivo	12684500

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Zhang[2009]_307	chr22:19046936-19795835 (Affymetrix SNP 6.0 array reference genome)	748899		Singleton deletions

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
22q11	chr22:15000000-25500000	1 (0/1/0)
22q11.2	chr22:17400000-25500000	2 (0/2/0)
Chr 22	chr22:0-50818468	2 (0/1/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16380905	This gene is not suggestive to SZ/SZA.	Negative

Gene relationship with MDD

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Region: chr22:20394115..20408461 View in gBrowse