Gene Report

Basic Info
Approved Symbol MYO5B
Symbol Alias KIAA1119
Approved Name myosin VB
Location 18q
Position chr18:49822813-50195093, -1
External Links HGNC: 7603
Entrez Gene: 4645
Ensembl: ENSG00000167306
UCSC: uc002leb.2
No. of Studies 2 (Positive: 1; Negative: 0; trend: 1)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Sklar, P., 2008 SNP: rs4939921 Our strongest single SNP results are found in myosin5B (MYO5B; P-value = 1.66E-07). Haplotype analysis further supported single SNP results highlighting MYO5B (P value=2.04E-08) Trend Comment on Study
Johnson, C.,2009 Monte-Carlo Simulation P-value = 0.0003. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 19)

GO terms by PBA (count: 2)

GO terms by database search (count: 17)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 8)

Related other genetic factors
Gene related SNPs (count: 2)

Literature-origin SNPs (count: 1)

LD-proxies (count: 1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 9)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr18:49822813..50195093 View in gBrowse
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