Gene Report

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Basic Info

Approved Symbol	HTR1E
Symbol Alias	5-HT1E
Approved Name	5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
Previous Name	5-hydroxytryptamine (serotonin) receptor 1E
Location	6q14-q15
Position	chr6:86937306-87016683, 1
External Links	HGNC: 5291 Entrez Gene: 3354 Ensembl: ENSG00000168830 UCSC: uc003pli.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Mundo, E.,2001		Our results are not suggestive of a direct involvement of the HTR1Eeta receptor gene in conferring risk to BP.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007268	synaptic transmission	biological process	IEA	116
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0005887	integral component of plasma membrane	cellular component	IMP[21422162]	158

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004993	serotonin receptor activity	molecular function	IDA[1608964]; IMP[21422162]	12
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	TAS[1733778]	17
GO:0051378	serotonin binding	molecular function	IDA[1608964]	6
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0004930	G-protein coupled receptor activity	molecular function	TAS[1733778]	26
GO:0030815	negative regulation of cAMP metabolic process	biological process	IEA	1
GO:0007210	serotonin receptor signaling pathway	biological process	IDA[1608964]; IEA; IMP[21422162]	12
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	biological process	IMP[21422162]	10
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[1608964]	64

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs9450594	chr6:86928621 - 86928621(1)		1(1/0/0)
rs10944288	chr6:86942024 - 86942024(1)	intron_variant	1(1/0/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q14-22	chr6:75200000-130000000	1 (0/0/1)
6q14	chr6:75200000-87300000	1 (0/0/1)
6q13-q14	chr6:69200000-87300000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr6:86937306..87016683 View in gBrowse