Reference |
Tested Markers |
Statistical Values/Author Comments |
Result Category |
Comment on Study |
Souery, D.,1996(b) |
Other variant: DRD3_BalI Polymorphism |
Association and linkage disequilibrium were excluded between bipolar affective disorder and these four candidate genes in our sample. |
Negative
|
Comment on Study |
Lee, S. Y.,2012(a) |
Other variant: DRD3_Ser9Gly |
We provide initial evidence that the BDNF Val66Met and DRD3 Ser9Gly genotypes interact only in bipolar-II disorder and that bipolar-I and bipolar-II may be genetically distinct. |
Positive
|
Comment on Study |
Szczepankiewicz, A., 2007 |
Other variant: DRD3_Ser9Gly |
We have not found any significant differences in genotype distribution of the polymorphisms of this dopamine gene between bipolar disorder patients with/without comorbid alcohol abuse and controls. |
Negative
|
Comment on Study |
Van Den Bogaert, A., 2006 (b) |
Other variant: DRD3_Ser9Gly |
Together, our data suggest that these functional variants are not involved in the etiology of bipolar disorder in the northern Swedish population nor did gene-gene interaction analysis support a central role of these variants in bipolar disorder.. |
Negative
|
Comment on Study |
Savoye, C., 1998 |
Other variant: D3_Msc1 |
Single mutations of either of the studied receptor genes are not major determinants of MDI. |
Negative
|
Comment on Study |
Serretti, A.,2000(b) |
Other variant: DRD3_exon1_D3 polymorphism |
The D2 and D3 dopamine receptors were, therefore, not a major liability factor for mood disorders in our sample. |
Negative
|
Comment on Study |
Piccardi, M. P., 1997 |
Other variant: DRD3_allele1/allele2 |
Using the Bal I restriction enzyme site polymorphism of Lannfelt et al. (1992), no differences were found between transmitted and non-transmitted alleles and no evidence of linkage disequilibrium was observed. |
Negative
|
Comment on Study |
Kirov, G.,1999(a) |
Other variant: DRD3_BalI Polymorphism |
No statistically significant differences were found between transmitted and not transmitted alleles for any of the polymorphisms studied. |
Negative
|
Comment on Study |
Chang, Y. H.,2013 |
Other variant: DRD3_Ser9Gly |
The involvement of the dopaminergic pathway in AD was confirmed, particularly with BP-II rather than BP-I. Because the Val/Val genotype of the BDNF Val66Met polymorphism, rather than the other two polymorphisms, has been associated with anxiety, it seems to affect BP-I comorbid with AD without the involvement of the DRD3 Seg9Gly polymorphism, but may modify the involvement of DRD3 Gly/Gly in BP-II comorbid with AD. |
Positive
|
Comment on Study |
Li, T.,1999 |
Other variant: DRD3_Ser9Gly |
No significant differences in both allele frequency and genotype frequency were found. |
Negative
|
Comment on Study |
Manki, H.,1996 |
Other variant: DRD3_Ser9Gly |
Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders. |
Negative
|
Comment on Study |
Leszczynska-Rodziewicz, A.,2005 |
Other variant: DRD3_Ser9Gly |
The results suggests that the studied gene variants of type D2 dopamine receptors are not promising candidate genes for bipolar affective illness. |
Negative
|
Comment on Study |
Lin, C. I.,2010 |
Haplotype: (DRD3_Ser9Gly) - (5-HTTLPR)() Other variant: DRD3_Ser9Gly |
We suggested that the distinction between BP-I and BP-II relies on the interaction of DRD3 Ser9Gly genotypes with NS. This result provides initial evidence that the DRD3 Ser9Gly genotypes are moderating the association between NS and bipolar disorders. |
Positive
|
Comment on Study |
Massat, I.,2002(b) |
Other variant: DRD3_Ser9Gly |
No association was found for DRD3 in BPAD. |
Negative
|
Comment on Study |
Elvidge, G.,2001 |
Other variant: DRD3_BalI Polymorphism |
In view of this evidence, we conclude that variation at the BalI RFLP is not an important factor influencing the susceptibility to bipolar disorder. |
Negative
|
Comment on Study |
Mitchell, P.,1993 |
Other variant: DRD3_BalI Polymorphism |
No significant association between bipolar affective disorder and DRD3 was found. |
Negative
|
Comment on Study |
Rietschel, M.,1993 |
Other variant: DRD3_BalI Polymorphism |
allelic P-value = 0.69, X<sup>2</sup> = 0.16.
No significant association between bipolar affective disorder and DRD3 was found. |
Negative
|
Comment on Study |
Parsian, A.,1995 |
Other variant: DRD3_BalI Polymorphism |
Fisher's exact test for transmitted vs nontransmitted p-value = 0.04.
When using the transmitted allele relative risk approach, we do find statistically significant evidence for the specific association of allele 1 of the dopamine D3 receptor gene with bipolar affective disorder |
Positive
|
Comment on Study |
Fallin, M. D.,2005 |
|
5 SNP typed, Median D'=0.88, Median r<sup>2</sup> =0.3, 1 LD blocks, 0.55 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA...
This gene is not suggestive to BP. |
Negative
|
Comment on Study |