Gene Report

Basic Info
Approved Symbol DRD3
Approved Name dopamine receptor D3
Location 3q13.3
Position chr3:114128652-114199407, -1
External Links HGNC: 3024
Entrez Gene: 1814
Ensembl: ENSG00000151577
UCSC: uc010hqn.1
No. of Studies 19 (Positive: 4; Negative: 15; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 19)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Souery, D.,1996(b) Other variant: DRD3_BalI Polymorphism Association and linkage disequilibrium were excluded between bipolar affective disorder and these four candidate genes in our sample. Negative Comment on Study
Lee, S. Y.,2012(a) Other variant: DRD3_Ser9Gly We provide initial evidence that the BDNF Val66Met and DRD3 Ser9Gly genotypes interact only in bipolar-II disorder and that bipolar-I and bipolar-II may be genetically distinct. Positive Comment on Study
Szczepankiewicz, A., 2007 Other variant: DRD3_Ser9Gly We have not found any significant differences in genotype distribution of the polymorphisms of this dopamine gene between bipolar disorder patients with/without comorbid alcohol abuse and controls. Negative Comment on Study
Van Den Bogaert, A., 2006 (b) Other variant: DRD3_Ser9Gly Together, our data suggest that these functional variants are not involved in the etiology of bipolar disorder in the northern Swedish population nor did gene-gene interaction analysis support a central role of these variants in bipolar disorder.. Negative Comment on Study
Savoye, C., 1998 Other variant: D3_Msc1 Single mutations of either of the studied receptor genes are not major determinants of MDI. Negative Comment on Study
Serretti, A.,2000(b) Other variant: DRD3_exon1_D3 polymorphism The D2 and D3 dopamine receptors were, therefore, not a major liability factor for mood disorders in our sample. Negative Comment on Study
Piccardi, M. P., 1997 Other variant: DRD3_allele1/allele2 Using the Bal I restriction enzyme site polymorphism of Lannfelt et al. (1992), no differences were found between transmitted and non-transmitted alleles and no evidence of linkage disequilibrium was observed. Negative Comment on Study
Kirov, G.,1999(a) Other variant: DRD3_BalI Polymorphism No statistically significant differences were found between transmitted and not transmitted alleles for any of the polymorphisms studied. Negative Comment on Study
Chang, Y. H.,2013 Other variant: DRD3_Ser9Gly The involvement of the dopaminergic pathway in AD was confirmed, particularly with BP-II rather than BP-I. Because the Val/Val genotype of the BDNF Val66Met polymorphism, rather than the other two polymorphisms, has been associated with anxiety, it seems to affect BP-I comorbid with AD without the involvement of the DRD3 Seg9Gly polymorphism, but may modify the involvement of DRD3 Gly/Gly in BP-II comorbid with AD. Positive Comment on Study
Li, T.,1999 Other variant: DRD3_Ser9Gly No significant differences in both allele frequency and genotype frequency were found. Negative Comment on Study
Manki, H.,1996 Other variant: DRD3_Ser9Gly Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders. Negative Comment on Study
Leszczynska-Rodziewicz, A.,2005 Other variant: DRD3_Ser9Gly The results suggests that the studied gene variants of type D2 dopamine receptors are not promising candidate genes for bipolar affective illness. Negative Comment on Study
Lin, C. I.,2010 Haplotype: (DRD3_Ser9Gly) - (5-HTTLPR)()
Other variant: DRD3_Ser9Gly
We suggested that the distinction between BP-I and BP-II relies on the interaction of DRD3 Ser9Gly genotypes with NS. This result provides initial evidence that the DRD3 Ser9Gly genotypes are moderating the association between NS and bipolar disorders. Positive Comment on Study
Massat, I.,2002(b) Other variant: DRD3_Ser9Gly No association was found for DRD3 in BPAD. Negative Comment on Study
Elvidge, G.,2001 Other variant: DRD3_BalI Polymorphism In view of this evidence, we conclude that variation at the BalI RFLP is not an important factor influencing the susceptibility to bipolar disorder. Negative Comment on Study
Mitchell, P.,1993 Other variant: DRD3_BalI Polymorphism No significant association between bipolar affective disorder and DRD3 was found. Negative Comment on Study
Rietschel, M.,1993 Other variant: DRD3_BalI Polymorphism allelic P-value = 0.69, X<sup>2</sup> = 0.16. No significant association between bipolar affective disorder and DRD3 was found. Negative Comment on Study
Parsian, A.,1995 Other variant: DRD3_BalI Polymorphism Fisher's exact test for transmitted vs nontransmitted p-value = 0.04. When using the transmitted allele relative risk approach, we do find statistically significant evidence for the specific association of allele 1 of the dopamine D3 receptor gene with bipolar affective disorder Positive Comment on Study
Fallin, M. D.,2005 5 SNP typed, Median D'=0.88, Median r<sup>2</sup> =0.3, 1 LD blocks, 0.55 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 62)

GO terms by PBA (count: 5)

GO terms by database search (count: 57)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 13)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 5)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 68)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 2)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr3:114128652..114199407 View in gBrowse
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