Gene Report

Approved Symbol	DRD3
Approved Name	dopamine receptor D3
Location	3q13.3
Position	chr3:114128652-114199407, -1
External Links	HGNC: 3024 Entrez Gene: 1814 Ensembl: ENSG00000151577 UCSC: uc010hqn.1
No. of Studies	19 (Positive: 4; Negative: 15; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Souery, D.,1996(b)	Other variant: DRD3_BalI Polymorphism	Association and linkage disequilibrium were excluded between bipolar affective disorder and these four candidate genes in our sample.	Negative	Comment on Study
Lee, S. Y.,2012(a)	Other variant: DRD3_Ser9Gly	We provide initial evidence that the BDNF Val66Met and DRD3 Ser9Gly genotypes interact only in bipolar-II disorder and that bipolar-I and bipolar-II may be genetically distinct.	Positive	Comment on Study
Szczepankiewicz, A., 2007	Other variant: DRD3_Ser9Gly	We have not found any significant differences in genotype distribution of the polymorphisms of this dopamine gene between bipolar disorder patients with/without comorbid alcohol abuse and controls.	Negative	Comment on Study
Van Den Bogaert, A., 2006 (b)	Other variant: DRD3_Ser9Gly	Together, our data suggest that these functional variants are not involved in the etiology of bipolar disorder in the northern Swedish population nor did gene-gene interaction analysis support a central role of these variants in bipolar disorder..	Negative	Comment on Study
Savoye, C., 1998	Other variant: D3_Msc1	Single mutations of either of the studied receptor genes are not major determinants of MDI.	Negative	Comment on Study
Serretti, A.,2000(b)	Other variant: DRD3_exon1_D3 polymorphism	The D2 and D3 dopamine receptors were, therefore, not a major liability factor for mood disorders in our sample.	Negative	Comment on Study
Piccardi, M. P., 1997	Other variant: DRD3_allele1/allele2	Using the Bal I restriction enzyme site polymorphism of Lannfelt et al. (1992), no differences were found between transmitted and non-transmitted alleles and no evidence of linkage disequilibrium was observed.	Negative	Comment on Study
Kirov, G.,1999(a)	Other variant: DRD3_BalI Polymorphism	No statistically significant differences were found between transmitted and not transmitted alleles for any of the polymorphisms studied.	Negative	Comment on Study
Chang, Y. H.,2013	Other variant: DRD3_Ser9Gly	The involvement of the dopaminergic pathway in AD was confirmed, particularly with BP-II rather than BP-I. Because the Val/Val genotype of the BDNF Val66Met polymorphism, rather than the other two polymorphisms, has been associated with anxiety, it seems to affect BP-I comorbid with AD without the involvement of the DRD3 Seg9Gly polymorphism, but may modify the involvement of DRD3 Gly/Gly in BP-II comorbid with AD.	Positive	Comment on Study
Li, T.,1999	Other variant: DRD3_Ser9Gly	No significant differences in both allele frequency and genotype frequency were found.	Negative	Comment on Study
Manki, H.,1996	Other variant: DRD3_Ser9Gly	Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders.	Negative	Comment on Study
Leszczynska-Rodziewicz, A.,2005	Other variant: DRD3_Ser9Gly	The results suggests that the studied gene variants of type D2 dopamine receptors are not promising candidate genes for bipolar affective illness.	Negative	Comment on Study
Lin, C. I.,2010	Haplotype: (DRD3_Ser9Gly) - (5-HTTLPR)() Other variant: DRD3_Ser9Gly	We suggested that the distinction between BP-I and BP-II relies on the interaction of DRD3 Ser9Gly genotypes with NS. This result provides initial evidence that the DRD3 Ser9Gly genotypes are moderating the association between NS and bipolar disorders.	Positive	Comment on Study
Massat, I.,2002(b)	Other variant: DRD3_Ser9Gly	No association was found for DRD3 in BPAD.	Negative	Comment on Study
Elvidge, G.,2001	Other variant: DRD3_BalI Polymorphism	In view of this evidence, we conclude that variation at the BalI RFLP is not an important factor influencing the susceptibility to bipolar disorder.	Negative	Comment on Study
Mitchell, P.,1993	Other variant: DRD3_BalI Polymorphism	No significant association between bipolar affective disorder and DRD3 was found.	Negative	Comment on Study
Rietschel, M.,1993	Other variant: DRD3_BalI Polymorphism	allelic P-value = 0.69, X<sup>2</sup> = 0.16. No significant association between bipolar affective disorder and DRD3 was found.	Negative	Comment on Study
Parsian, A.,1995	Other variant: DRD3_BalI Polymorphism	Fisher's exact test for transmitted vs nontransmitted p-value = 0.04. When using the transmitted allele relative risk approach, we do find statistically significant evidence for the specific association of allele 1 of the dopamine D3 receptor gene with bipolar affective disorder	Positive	Comment on Study
Fallin, M. D.,2005		5 SNP typed, Median D'=0.88, Median r<sup>2</sup> =0.3, 1 LD blocks, 0.55 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP.	Negative	Comment on Study

Region: chr3:114128652..114199407 View in gBrowse