Gene Report

Basic Info
Approved Symbol TLR4
Symbol Alias hToll, CD284, TLR-4, ARMD10
Approved Name toll-like receptor 4
Location 9q33.1
Position chr9:117704332-117716871, 1
External Links HGNC: 11850
Entrez Gene: 7099
Ensembl: ENSG00000136869
UCSC: uc004bjz.4
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Oliveira, J., 2013 SNP: rs1927914, rs11536891 We report for the first time a genetic association between BD and TLR-4 a major player of innate immunity. Possible mechanisms underlying bipolar disorders linking altered TLR-4 expression and increased susceptibility to infections and/or autoimmunity are discussed. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 77)

GO terms by PBA (count: 5)

GO terms by database search (count: 72)

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 3)

Gene related BioCarta pathways (count: 4)

Gene related interactors from protein-protein interactions data in HPRD (count: 21)

Related other genetic factors
Gene related SNPs (count: 6)

Literature-origin SNPs (count: 2)

LD-proxies (count: 4)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr9:117704332..117716871 View in gBrowse
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