Gene Report

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Basic Info

Approved Symbol	LIMS2
Approved Name	LIM and senescent cell antigen-like domains 2
Location	2q21.1
Position	chr2:127638381-127681786, -1
External Links	HGNC: 16084 Entrez Gene: 55679 Ensembl: ENSG00000072163 UCSC: uc010yzm.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Drago, A., 2016		Freq(Significant SNPs/total SNPs%)=0.02. Encodes for member of a small family of focal adhesion proteins and is involved in the modulation of cell spreading and migration. This adapter protein links beta-integrins to the actin cytoskeleton, and bridges this cytoplasmic complex to cell surface receptor tyrosine kinases and growth factor receptors.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IEA	283
GO:0005886	plasma membrane	cellular component	IEA	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0034329	cell junction assembly	biological process	TAS	8
GO:0045216	cell-cell junction organization	biological process	IEA	8
GO:0005829	cytosol	cellular component	TAS	223
GO:2000178	negative regulation of neural precursor cell proliferation	biological process	IEA	2
GO:2001046	positive regulation of integrin-mediated signaling pathway	biological process	IEA	1
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0016337	single organismal cell-cell adhesion	biological process	IEA	10
GO:0008270	zinc ion binding	molecular function	IEA	77
GO:0005925	focal adhesion	cellular component	IDA[21423176]	32
GO:2000346	negative regulation of hepatocyte proliferation	biological process	IEA	2
GO:0043066	negative regulation of apoptotic process	biological process	IEA	46

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
LIMS2	ILK	NO	in vitro;in vivo	12167643
LIMS2	HIPK3	NO	yeast 2-hybrid	15231748

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2q14.3	chr2:121600000-129100000	1 (0/0/1)
2q12.3-q22.1	chr2:106700000-141500000	1 (0/1/0)
Chr 2	chr2:0-242193529	3 (0/3/0)
2p11-q14	chr2:83100000-129100000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr2:127638381..127681786 View in gBrowse