Gene Report

ADD to My Gene Set

Basic Info

Approved Symbol	SLU7
Symbol Alias	9G8
Approved Name	SLU7 splicing factor homolog (S. cerevisiae)
Name Alias	zinc knuckle motif containing
Location	5q33.3
Position	chr5:160401641-160421711, -1
External Links	HGNC: 16939 Entrez Gene: 10569 Ensembl: ENSG00000164609 UCSC: uc003lyg.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Cruceanu, C., 2013	Other variant: SLU7_Chr5:159840980_T/C	Rare variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0000375	RNA splicing, via transesterification reactions	biological process	IDA[10197984]	2
GO:0016020	membrane	cellular component	IDA[19946888]	137
GO:0000398	mRNA splicing, via spliceosome	biological process	IC[11991638]	6
GO:0005634	nucleus	cellular component	IDA[21122810]	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0000386	second spliceosomal transesterification activity	molecular function	IDA[10197984]	1
GO:0030628	pre-mRNA 3'-splice site binding	molecular function	IDA[15728250]	1
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0071013	catalytic step 2 spliceosome	cellular component	IDA[11991638]	4
GO:0005515	protein binding	molecular function	IPI[16189514]	563
GO:0043231	intracellular membrane-bounded organelle	cellular component	IDA	34
GO:0016607	nuclear speck	cellular component	IDA[15728250]	16
GO:0005681	spliceosomal complex	cellular component	IDA[10197984]	6
GO:0006886	intracellular protein transport	biological process	IDA[21122810]	10
GO:0008270	zinc ion binding	molecular function	IDA[15181151]	77
GO:0000389	mRNA 3'-splice site recognition	biological process	IDA[15728250]	1
GO:0034605	cellular response to heat	biological process	IDA[21122810]	11
GO:0000380	alternative mRNA splicing, via spliceosome	biological process	IDA[15728250]	3
GO:0030532	small nuclear ribonucleoprotein complex	cellular component	IDA[15181151]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
SLU7	PPIL3	NO	yeast 2-hybrid	16189514
SLU7	CCDC85B	NO	yeast 2-hybrid	16189514

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
SLU7_Chr5:159840980_T/C	Missense	Chr5:159840980	1 (0/0/1)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 5	chr5:0-181538259	3 (0/2/1)
5q31-q33	chr5:131200000-160500000	1 (1/0/0)
5q32-5q33.3	chr5:145100000-160500000	1 (0/1/0)
5q33	chr5:150400000-160500000	2 (0/1/1)
5q33-34	chr5:150400000-169000000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr5:160401641..160421711 View in gBrowse