Gene Report

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Basic Info

Approved Symbol	SLU7
Symbol Alias	9G8
Approved Name	SLU7 splicing factor homolog (S. cerevisiae)
Name Alias	zinc knuckle motif containing
Location	5q33.3
Position	chr5:160401641-160421711, -1
External Links	HGNC: 16939 Entrez Gene: 10569 Ensembl: ENSG00000164609 UCSC: uc003lyg.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Cruceanu, C., 2013	Other variant: SLU7_Chr5:159840980_T/C	Rare variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0000375	RNA splicing, via transesterification reactions	biological process	IDA[10197984]	2
GO:0016020	membrane	cellular component	IDA[19946888]	137
GO:0000398	mRNA splicing, via spliceosome	biological process	IC[11991638]	6
GO:0005634	nucleus	cellular component	IDA[21122810]	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0000386	second spliceosomal transesterification activity	molecular function	IDA[10197984]	1
GO:0030628	pre-mRNA 3'-splice site binding	molecular function	IDA[15728250]	1
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0071013	catalytic step 2 spliceosome	cellular component	IDA[11991638]	4
GO:0005515	protein binding	molecular function	IPI[16189514]	563
GO:0043231	intracellular membrane-bounded organelle	cellular component	IDA	34
GO:0016607	nuclear speck	cellular component	IDA[15728250]	16
GO:0005681	spliceosomal complex	cellular component	IDA[10197984]	6
GO:0006886	intracellular protein transport	biological process	IDA[21122810]	10
GO:0008270	zinc ion binding	molecular function	IDA[15181151]	77
GO:0000389	mRNA 3'-splice site recognition	biological process	IDA[15728250]	1
GO:0034605	cellular response to heat	biological process	IDA[21122810]	11
GO:0000380	alternative mRNA splicing, via spliceosome	biological process	IDA[15728250]	3
GO:0030532	small nuclear ribonucleoprotein complex	cellular component	IDA[15181151]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
SLU7	CCDC85B	NO	yeast 2-hybrid	16189514
SLU7	PPIL3	NO	yeast 2-hybrid	16189514

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
SLU7_Chr5:159840980_T/C	Missense	Chr5:159840980	1 (0/0/1)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 5	chr5:0-181538259	3 (0/2/1)
5q31-q33	chr5:131200000-160500000	1 (1/0/0)
5q32-5q33.3	chr5:145100000-160500000	1 (0/1/0)
5q33	chr5:150400000-160500000	2 (0/1/1)
5q33-34	chr5:150400000-169000000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr5:160401641..160421711 View in gBrowse