Gene Report

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Basic Info

Approved Symbol	NRGN
Symbol Alias	RC3
Approved Name	neurogranin (protein kinase C substrate, RC3)
Location	11q24
Position	chr11:124739846-124747210, 1
External Links	HGNC: 8000 Entrez Gene: 4900 Ensembl: ENSG00000154146 UCSC: uc001qar.2
No. of Studies	2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Williams, H. J.,2011	SNP: rs12807809	Using data sets entirely independent of their original discoveries, we observed nominally significant evidence (P < 0.05) that the extended MHC region is associated with BD.	Positive	Comment on Study
Steinberg, S.,2012	SNP: rs12807809	No significant association was observed.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005516	calmodulin binding	molecular function	IEA	20
GO:0007399	nervous system development	biological process	TAS[10075657]	40

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005622	intracellular	cellular component	IBA	17
GO:0007165	signal transduction	biological process	TAS[10075657]	136
GO:0035556	intracellular signal transduction	biological process	IBA	38

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
NRGN	PRKCG	NO	in vitro	8080473
NRGN	PRKCA	NO	in vitro	8080473
NRGN	CALM1	NO	in vitro;in vivo;yeast 2-hybrid	10075657
NRGN	PRKCB	NO	in vitro	8080473

Related other genetic factors

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs12807809	chr11:124736389 - 124736389(1)	upstream_gene_variant	2(1/1/0)
rs12278912	chr11:124742263 - 124742263(1)	downstream_gene_variant; intron_variant	1(0/1/0)
rs7113041	chr11:124742695 - 124742695(1)	downstream_gene_variant; intron_variant	1(1/0/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 11	chr11:0-135086622	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
23164818	Association results in schizophrenia follow-up samples(10,671 cases; 23,900 controls):OR(95% CI) = 1.09 (1.04, 1.15),P-value = 0.00034. No significant association was observed.	Negative

Gene relationship with MDD

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Region: chr11:124739846..124747210 View in gBrowse