Gene Report

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Basic Info

Approved Symbol	NRGN
Symbol Alias	RC3
Approved Name	neurogranin (protein kinase C substrate, RC3)
Location	11q24
Position	chr11:124739846-124747210, 1
External Links	HGNC: 8000 Entrez Gene: 4900 Ensembl: ENSG00000154146 UCSC: uc001qar.2
No. of Studies	2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Williams, H. J.,2011	SNP: rs12807809	Using data sets entirely independent of their original discoveries, we observed nominally significant evidence (P < 0.05) that the extended MHC region is associated with BD.	Positive	Comment on Study
Steinberg, S.,2012	SNP: rs12807809	No significant association was observed.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005516	calmodulin binding	molecular function	IEA	20
GO:0007399	nervous system development	biological process	TAS[10075657]	40

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005622	intracellular	cellular component	IBA	17
GO:0007165	signal transduction	biological process	TAS[10075657]	136
GO:0035556	intracellular signal transduction	biological process	IBA	38

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
NRGN	PRKCG	NO	in vitro	8080473
NRGN	PRKCB	NO	in vitro	8080473
NRGN	PRKCA	NO	in vitro	8080473
NRGN	CALM1	NO	in vitro;in vivo;yeast 2-hybrid	10075657

Related other genetic factors

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs12807809	chr11:124736389 - 124736389(1)	upstream_gene_variant	2(1/1/0)
rs12278912	chr11:124742263 - 124742263(1)	downstream_gene_variant; intron_variant	1(0/1/0)
rs7113041	chr11:124742695 - 124742695(1)	downstream_gene_variant; intron_variant	1(1/0/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 11	chr11:0-135086622	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
23164818	Association results in schizophrenia follow-up samples(10,671 cases; 23,900 controls):OR(95% CI) = 1.09 (1.04, 1.15),P-value = 0.00034. No significant association was observed.	Negative

Gene relationship with MDD

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Region: chr11:124739846..124747210 View in gBrowse