Gene Report

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Basic Info

Approved Symbol	MARCH1
Symbol Alias	FLJ20668, MARCH-I, RNF171
Approved Name	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
Previous Name	membrane-associated ring finger (C3HC4) 1
Location	4q32.2
Position	chr4:163524298-164384050, -1
External Links	HGNC: 26077 Entrez Gene: 55016 Ensembl: ENSG00000145416 UCSC: uc003iqs.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs10023321	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005764	lysosome	cellular component	IDA[14722266]	16
GO:0005886	plasma membrane	cellular component	IDA[19117940]	360
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0042287	MHC protein binding	molecular function	IDA[18389477]	1
GO:0008270	zinc ion binding	molecular function	IEA	77
GO:0002495	antigen processing and presentation of peptide antigen via MHC class II	biological process	IDA[18389477]	1
GO:0005768	endosome	cellular component	IDA[14722266]	27
GO:0000209	protein polyubiquitination	biological process	IDA[19117940]	7
GO:0004842	ubiquitin-protein transferase activity	molecular function	IDA[14722266]	12
GO:0006955	immune response	biological process	IDA[18305173]	19
GO:0005765	lysosomal membrane	cellular component	ISS	14
GO:0016874	ligase activity	molecular function	IEA	16
GO:0030659	cytoplasmic vesicle membrane	cellular component	IEA	12
GO:0005789	endoplasmic reticulum membrane	cellular component	ISS	52
GO:0031902	late endosome membrane	cellular component	IDA[19117940]	5
GO:0032588	trans-Golgi network membrane	cellular component	ISS	4
GO:0031901	early endosome membrane	cellular component	IDA[19117940]	8

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs10023321	chr4:163799891 - 163799891(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 4	chr4:0-190214555	3 (0/3/0)
4q31.22-34.1	chr4:145900000-175400000	1 (0/0/1)
4q32	chr4:154600000-169200000	3 (0/0/3)
4q31-35	chr4:138500000-190214555	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr4:163524298..164384050 View in gBrowse