Gene Report

Basic Info
Approved Symbol CHRNA7
Approved Name cholinergic receptor, nicotinic, alpha 7 (neuronal)
Previous Name cholinergic receptor, nicotinic, alpha polypeptide 7
Name Alias acetylcholine receptor, nicotinic, alpha 7 (neuronal)
Location 15q13.3
Position chr15:31923438-32173018, 1
External Links HGNC: 1960
Entrez Gene: 1139
Ensembl: ENSG00000175344
UCSC: uc001zft.4
No. of Studies 4 (Positive: 2; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 4)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Ancin, I.,2011(a) SNP: rs6494223, rs883473, rs904952
Haplotype: (CHRNA7_-86C/T) - rs883473 - rs6494223 - rs904952(C-C-C-C), (CHRNA7_-86C/T) - rs883473 - rs6494223 - rs904952(C-C-C-T), (CHRNA7_-86C/T) - rs883473 - rs6494223 - rs904952(C-C-T-C), (CHRNA7_-86C/T) - rs883473 - rs6494223 - rs904952(C-C-T-T), (CHRNA7_-86C/T) - rs883473 - rs6494223 - rs904952(C-T-C-C), (CHRNA7_-86C/T) - rs883473 - rs6494223 - rs904952(C-T-C-T), (CHRNA7_-86C/T) - rs883473 - rs6494223 - rs904952(C-T-T-C), (CHRNA7_-86C/T) - rs883473 - rs6494223 - rs904952(C-T-T-T), (CHRNA7_-86C/T) - rs883473 - rs6494223 - rs904952(T-C-C-C), (CHRNA7_-86C/T) - rs883473 - rs6494223 - rs904952(T-C-C-T)
Other variant: CHRNA7_-86C/T
The promoter polymorphism did not show effects in our study, but several candidate polymorphisms showed significant associations with different measures of the neuropsychological task for bipolar group. Negative Comment on Study
Hong, C. J., 2004 Other variant: -2 bp deletion polymorphism A -2 bp deletion polymorphism has been found in the duplicated CHRNA7 (CHRNA7-like) gene. The distribution of -2 bp genotypes showed a moderately significant difference between the BPD patients and controls. Positive Comment on Study
Joo, E. J.,2010 SNP: rs12916879, rs2337506, rs6494223 We could not replicate positive association in other ethnic groups previously studied. Negative Comment on Study
Shi, J., 2007 SNP: rs13329490, rs1355920, rs1500946, rs1913456, rs2337980, rs4779971, rs7179733, rs8035668, rs904951, rs965435
Haplotype: rs8035668 - rs1500946(C-A)
haploview analyses showed nominally significant transmission bias of rs8035668-rs1500946; no evidence of interaction among these 19 cholinergic genes by FITF analysis and FDR correction was found Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 28)

GO terms by PBA (count: 6)

GO terms by database search (count: 22)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Related other genetic factors
Gene related SNPs (count: 68)

Literature-origin SNPs (count: 15)

LD-proxies (count: 53)

Gene related CNVs (count: 2)

Gene related other variants (count: 2)

Gene related regions (count: 1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 15)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr15:31923438..32173018 View in gBrowse
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