Gene Report

Approved Symbol	CHRNA7
Approved Name	cholinergic receptor, nicotinic, alpha 7 (neuronal)
Previous Name	cholinergic receptor, nicotinic, alpha polypeptide 7
Name Alias	acetylcholine receptor, nicotinic, alpha 7 (neuronal)
Location	15q13.3
Position	chr15:31923438-32173018, 1
External Links	HGNC: 1960 Entrez Gene: 1139 Ensembl: ENSG00000175344 UCSC: uc001zft.4
No. of Studies	4 (Positive: 2; Negative: 2; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Ancin, I.,2011(a)	SNP: rs6494223, rs883473, rs904952 Haplotype: (CHRNA7_-86C/T) - rs883473 - rs6494223 - rs904952(C-C-C-C), (CHRNA7_-86C/T) - rs883473 - rs6494223 - rs904952(C-C-C-T), (CHRNA7_-86C/T) - rs883473 - rs6494223 - rs904952(C-C-T-C), (CHRNA7_-86C/T) - rs883473 - rs6494223 - rs904952(C-C-T-T), (CHRNA7_-86C/T) - rs883473 - rs6494223 - rs904952(C-T-C-C), (CHRNA7_-86C/T) - rs883473 - rs6494223 - rs904952(C-T-C-T), (CHRNA7_-86C/T) - rs883473 - rs6494223 - rs904952(C-T-T-C), (CHRNA7_-86C/T) - rs883473 - rs6494223 - rs904952(C-T-T-T), (CHRNA7_-86C/T) - rs883473 - rs6494223 - rs904952(T-C-C-C), (CHRNA7_-86C/T) - rs883473 - rs6494223 - rs904952(T-C-C-T) Other variant: CHRNA7_-86C/T	The promoter polymorphism did not show effects in our study, but several candidate polymorphisms showed significant associations with different measures of the neuropsychological task for bipolar group.	Negative	Comment on Study
Hong, C. J., 2004	Other variant: -2 bp deletion polymorphism	A -2 bp deletion polymorphism has been found in the duplicated CHRNA7 (CHRNA7-like) gene. The distribution of -2 bp genotypes showed a moderately significant difference between the BPD patients and controls.	Positive	Comment on Study
Joo, E. J.,2010	SNP: rs12916879, rs2337506, rs6494223	We could not replicate positive association in other ethnic groups previously studied.	Negative	Comment on Study
Shi, J., 2007	SNP: rs13329490, rs1355920, rs1500946, rs1913456, rs2337980, rs4779971, rs7179733, rs8035668, rs904951, rs965435 Haplotype: rs8035668 - rs1500946(C-A)	haploview analyses showed nominally significant transmission bias of rs8035668-rs1500946; no evidence of interaction among these 19 cholinergic genes by FITF analysis and FDR correction was found	Positive	Comment on Study

Region: chr15:31923438..32173018 View in gBrowse