Gene Report

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Basic Info

Approved Symbol	TEAD1
Previous Symbol	TCF13, AA
Symbol Alias	TEF-1
Approved Name	TEA domain family member 1 (SV40 transcriptional enhancer factor)
Previous Name	atrophia areata, peripapillary chorioretinal degeneration
Location	11p15.4
Position	chr11:12674591-12944483, 1
External Links	HGNC: 11714 Entrez Gene: 7003 Ensembl: ENSG00000187079 UCSC: uc021qdx.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs16911839	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IDA[18579750]	66
GO:0003677	DNA binding	molecular function	IEA	83

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006367	transcription initiation from RNA polymerase II promoter	biological process	TAS	20
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0005654	nucleoplasm	cellular component	IDA; TAS	163
GO:0005515	protein binding	molecular function	IPI[18579750]	563
GO:0010467	gene expression	biological process	TAS	41
GO:0035329	hippo signaling	biological process	IDA[18579750]	4
GO:0006355	regulation of transcription, DNA-templated	biological process	IEA	62
GO:0005794	Golgi apparatus	cellular component	IDA	60

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 11)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TEAD1	MYH7	NO	in vitro;yeast 2-hybrid	8253797 , 12861002
TEAD1	VGLL4	NO	in vitro	15140898
TEAD1	SRF	NO	in vitro;in vivo	12061776 , 11136726
TEAD1	YAP1	NO	in vitro;in vivo	11358867
TEAD1	MAX	NO	in vitro;in vivo	9199327
TEAD1	TBP	YES	in vitro	8423815
TEAD1	MEF2B	NO	in vitro	12861002
TEAD1	VGLL1	NO	in vitro;in vivo;yeast 2-hybrid	10518497
TEAD1	VGLL2	NO	in vitro;in vivo	12376544 , 14762206
TEAD1	MEF2A	NO	in vitro	12061776 , 12861002
TEAD1	MEF2C	NO	in vitro	12861002

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs16911839	chr11:12941575 - 12941575(1)	3_prime_UTR_variant; downstream_gene_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 11	chr11:0-135086622	2 (0/2/0)
11p15	chr11:0-22000000	5 (0/4/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr11:12674591..12944483 View in gBrowse