Gene Report

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Basic Info

Approved Symbol	TEAD1
Previous Symbol	TCF13, AA
Symbol Alias	TEF-1
Approved Name	TEA domain family member 1 (SV40 transcriptional enhancer factor)
Previous Name	atrophia areata, peripapillary chorioretinal degeneration
Location	11p15.4
Position	chr11:12674591-12944483, 1
External Links	HGNC: 11714 Entrez Gene: 7003 Ensembl: ENSG00000187079 UCSC: uc021qdx.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs16911839	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IDA[18579750]	66
GO:0003677	DNA binding	molecular function	IEA	83

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006367	transcription initiation from RNA polymerase II promoter	biological process	TAS	20
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0005654	nucleoplasm	cellular component	IDA; TAS	163
GO:0005515	protein binding	molecular function	IPI[18579750]	563
GO:0010467	gene expression	biological process	TAS	41
GO:0035329	hippo signaling	biological process	IDA[18579750]	4
GO:0006355	regulation of transcription, DNA-templated	biological process	IEA	62
GO:0005794	Golgi apparatus	cellular component	IDA	60

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 11)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TEAD1	MEF2B	NO	in vitro	12861002
TEAD1	MEF2C	NO	in vitro	12861002
TEAD1	TBP	YES	in vitro	8423815
TEAD1	MYH7	NO	in vitro;yeast 2-hybrid	8253797 , 12861002
TEAD1	MEF2A	NO	in vitro	12061776 , 12861002
TEAD1	VGLL2	NO	in vitro;in vivo	12376544 , 14762206
TEAD1	YAP1	NO	in vitro;in vivo	11358867
TEAD1	MAX	NO	in vitro;in vivo	9199327
TEAD1	SRF	NO	in vitro;in vivo	12061776 , 11136726
TEAD1	VGLL1	NO	in vitro;in vivo;yeast 2-hybrid	10518497
TEAD1	VGLL4	NO	in vitro	15140898

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs16911839	chr11:12941575 - 12941575(1)	3_prime_UTR_variant; downstream_gene_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 11	chr11:0-135086622	2 (0/2/0)
11p15	chr11:0-22000000	5 (0/4/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr11:12674591..12944483 View in gBrowse