Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	PROKR2
Previous Symbol	GPR73L1, KAL3
Symbol Alias	GPR73b, PKR2, GPRg2, dJ680N4.3
Approved Name	prokineticin receptor 2
Previous Name	G protein-coupled receptor 73-like 1, "Kallmann syndrome 3 (autosomal dominant)"
Location	20p12.3
Position	chr20:5302040-5314369, -1
External Links	HGNC: 15836 Entrez Gene: 128674 Ensembl: ENSG00000101292 UCSC: uc010zqw.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Kishi, T.,2009(c)	SNP: rs17721321, rs3746682, rs3746684, rs4815787, rs6085086 Haplotype: rs17721321 - rs6085086 - rs3746684 - rs3746682 - rs4815787()	In conclusion, our results suggest that PROKR2 probably plays a role in mood disorders(BD and MDD) in the Japanese population.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 5)

GO terms by PBA (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IDA[18826963]; TAS	360
GO:0016021	integral component of membrane	cellular component	IEA	219

GO terms by database search (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004983	neuropeptide Y receptor activity	molecular function	IEA	1
GO:0007623	circadian rhythm	biological process	IEA	40
GO:0007218	neuropeptide signaling pathway	biological process	IEA	18

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 51)

Literature-origin SNPs (count: 5)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs17721321	chr20:5315432 - 5315432(1)	upstream_gene_variant	1(1/0/0)
rs4815787	chr20:5301161 - 5301161(1)	downstream_gene_variant	1(0/1/0)
rs6085086	chr20:5312480 - 5312480(1)	intron_variant	1(0/1/0)
rs3746684	chr20:5302730 - 5302730(1)	synonymous_variant	1(0/1/0)
rs3746682	chr20:5302610 - 5302610(1)	synonymous_variant	1(1/0/0)

LD-proxies (count: 46)

rs_ID	Location	Functional Annotation
rs910971	chr20:5315842 - 5315842(1)	upstream_gene_variant
rs6053283	chr20:5309342 - 5309342(1)	intron_variant
rs4315595	chr20:5316547 - 5316547(1)	upstream_gene_variant
rs4544519	chr20:5316526 - 5316526(1)	upstream_gene_variant
rs910973	chr20:5316005 - 5316005(1)	upstream_gene_variant
rs910972	chr20:5315903 - 5315903(1)	upstream_gene_variant
rs4316997	chr20:5317213 - 5317213(1)	upstream_gene_variant
rs6053301	chr20:5318163 - 5318163(1)	upstream_gene_variant
rs4281978	chr20:5317338 - 5317338(1)	upstream_gene_variant
rs6053299	chr20:5315124 - 5315124(1)	upstream_gene_variant
rs6053298	chr20:5314829 - 5314829(1)	upstream_gene_variant
rs8116897	chr20:5313850 - 5313850(1)	intron_variant
rs7272559	chr20:5305529 - 5305529(1)	intron_variant
rs6053297	chr20:5314708 - 5314708(1)	upstream_gene_variant
rs8116536	chr20:5313815 - 5313815(1)	intron_variant
rs1884749	chr20:5317984 - 5317984(1)	upstream_gene_variant
rs3746680	chr20:5301913 - 5301913(1)	downstream_gene_variant
rs10485484	chr20:5298223 - 5298223(1)	downstream_gene_variant
rs6053286	chr20:5309856 - 5309856(1)	intron_variant
rs2145089	chr20:5302988 - 5302988(1)	intron_variant
rs1884748	chr20:5318022 - 5318022(1)	upstream_gene_variant
rs4813739	chr20:5319050 - 5319050(1)	upstream_gene_variant
rs7351709	chr20:5316152 - 5316152(1)	upstream_gene_variant
rs7270052	chr20:5300098 - 5300098(1)	downstream_gene_variant
rs6085092	chr20:5319360 - 5319360(1)	upstream_gene_variant
rs4815785	chr20:5300607 - 5300607(1)	downstream_gene_variant
rs7266208	chr20:5314920 - 5314920(1)	upstream_gene_variant
rs927102	chr20:5298669 - 5298669(1)	downstream_gene_variant
rs8120223	chr20:5315359 - 5315359(1)	upstream_gene_variant
rs927103	chr20:5298689 - 5298689(1)	downstream_gene_variant
rs17777716	chr20:5309729 - 5309729(1)	intron_variant
rs6053287	chr20:5309981 - 5309981(1)	intron_variant
rs6085085	chr20:5310012 - 5310012(1)	intron_variant
rs6053291	chr20:5311114 - 5311114(1)	intron_variant
rs6516015	chr20:5311440 - 5311440(1)	intron_variant
rs6076807	chr20:5311542 - 5311542(1)	intron_variant
rs6085088	chr20:5313273 - 5313273(1)	intron_variant
rs6516020	chr20:5313388 - 5313388(1)	intron_variant
rs4815788	chr20:5303635 - 5303635(1)	intron_variant
rs7270408	chr20:5304448 - 5304448(1)	intron_variant
rs6085077	chr20:5306147 - 5306147(1)	intron_variant
rs6076803	chr20:5306786 - 5306786(1)	intron_variant
rs7273837	chr20:5308835 - 5308835(1)	intron_variant
rs6053281	chr20:5308998 - 5308998(1)	intron_variant
rs5012083	chr20:5309156 - 5309156(1)	intron_variant
rs5012080	chr20:5309194 - 5309194(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
20p12	chr20:5100000-17900000	4 (0/0/4)
Chr 20	chr20:0-64444167	4 (0/3/1)
20pter-p12.3	chr20:0-9200000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Description	Category in MDD
19544013	In conclusion, our results suggest that PROKR2 probably plays a role in mood disorders(BD and MDD) in the Japanese population.	Positive

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr20:5302040..5314369 View in gBrowse