Gene Report

Basic Info
Approved Symbol PROKR2
Previous Symbol GPR73L1, KAL3
Symbol Alias GPR73b, PKR2, GPRg2, dJ680N4.3
Approved Name prokineticin receptor 2
Previous Name G protein-coupled receptor 73-like 1, "Kallmann syndrome 3 (autosomal dominant)"
Location 20p12.3
Position chr20:5302040-5314369, -1
External Links HGNC: 15836
Entrez Gene: 128674
Ensembl: ENSG00000101292
UCSC: uc010zqw.2
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Kishi, T.,2009(c) SNP: rs17721321, rs3746682, rs3746684, rs4815787, rs6085086
Haplotype: rs17721321 - rs6085086 - rs3746684 - rs3746682 - rs4815787()
In conclusion, our results suggest that PROKR2 probably plays a role in mood disorders(BD and MDD) in the Japanese population. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 5)

GO terms by PBA (count: 2)

GO terms by database search (count: 3)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 51)

Literature-origin SNPs (count: 5)

LD-proxies (count: 46)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr20:5302040..5314369 View in gBrowse
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