Gene Report

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Basic Info

Approved Symbol	PTPRN2
Symbol Alias	KIAA0387, phogrin, ICAAR, IA-2beta
Approved Name	protein tyrosine phosphatase, receptor type, N polypeptide 2
Name Alias	IAR PTPRP
Location	7q36
Position	chr7:157539056-158587788, -1
External Links	HGNC: 9677 Entrez Gene: 5799 Ensembl: ENSG00000155093 UCSC: uc003wno.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Curtis, D.,2011	SNP: rs6459804, rs6459806	There is a trend of this gene for significant association.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005887	integral component of plasma membrane	cellular component	TAS[8798755]	158
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	molecular function	TAS[8798755]	5
GO:0043235	receptor complex	cellular component	IDA[23382219]	20

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0043195	terminal bouton	cellular component	IEA	17
GO:0030141	secretory granule	cellular component	IEA	14
GO:0035335	peptidyl-tyrosine dephosphorylation	biological process	IEA; TAS[8798755]	9
GO:0030658	transport vesicle membrane	cellular component	IEA	4
GO:0006470	protein dephosphorylation	biological process	TAS[8798755]	10
GO:0005788	endoplasmic reticulum lumen	cellular component	IEA	8
GO:0034260	negative regulation of GTPase activity	biological process	IEA	2

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04940	Type I diabetes mellitus	10

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PTPRN2	SPTBN4	NO	in vivo;yeast 2-hybrid	11086001
PTPRN2	UBQLN4	NO	yeast 2-hybrid	16713569
PTPRN2	CKAP5	NO	yeast 2-hybrid	12421765

Related other genetic factors

Gene related SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6459804	chrCHR_HSCHR7_2_CTG7:157717503 - 157717503(1)	intron_variant	1(0/0/1)
rs6459806	chrCHR_HSCHR7_2_CTG7:157717791 - 157717791(1)	intron_variant	1(0/0/1)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs6459805		chrCHR_HSCHR7_2_CTG7:157717602 - 157717602(1)	intron_variant
rs10233396		chrCHR_HSCHR7_2_CTG7:157719598 - 157719598(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7q36.3	chr7:155200000-159345973	1 (0/0/1)
Chr 7	chr7:0-159345973	3 (0/3/0)
7q34-qter	chr7:138500000-159345973	1 (0/1/0)
7q36	chr7:148200000-159345973	3 (0/0/3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
21057379	There is a trend of this gene for significant association.	Trend

Gene relationship with MDD

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Region: chr7:157539056..158587788 View in gBrowse