Gene Report

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Basic Info

Approved Symbol	WIPF1
Previous Symbol	WASPIP
Symbol Alias	WIP
Approved Name	WAS/WASL interacting protein family, member 1
Previous Name	Wiskott-Aldrich syndrome protein interacting protein
Location	2q31.2
Position	chr2:174559572-174682916, -1
External Links	HGNC: 12736 Entrez Gene: 7456 Ensembl: ENSG00000115935 UCSC: uc002uiz.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Georgieva, L., 2014		A de novo CNV in this gene was detected in BD.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045087	innate immune response	biological process	TAS	49
GO:0003779	actin binding	molecular function	IEA	24

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005829	cytosol	cellular component	TAS	223
GO:0015629	actin cytoskeleton	cellular component	TAS[9405671]	18
GO:0008154	actin polymerization or depolymerization	biological process	IEA	1
GO:0006461	protein complex assembly	biological process	TAS[9405671]	11
GO:0030048	actin filament-based movement	biological process	IEA	2
GO:0005515	protein binding	molecular function	IPI[10202051]	563
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	biological process	TAS	9
GO:0005884	actin filament	cellular component	IEA	9
GO:0016023	cytoplasmic membrane-bounded vesicle	cellular component	IEA	16
GO:0001726	ruffle	cellular component	IEA	10
GO:0005522	profilin binding	molecular function	TAS[9405671]	2
GO:0051707	response to other organism	biological process	IEA	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 9)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
WIPF1	ACTC1	NO	in vivo	12029088
WIPF1	PRKCQ	NO	in vitro	12504004
WIPF1	WAS	NO	in vitro;in vivo;yeast 2-hybrid	9405671 , 12591280 , 16055720
WIPF1	ZAP70	NO	in vivo	12504004
WIPF1	WASL	NO	in vitro;in vivo	12372256 , 10087612 , 12437929 , 16055720
WIPF1	HCK	NO	in vivo	12029088
WIPF1	CTTN	YES	yeast 2-hybrid	12620186
WIPF1	CRKL	NO	in vitro;in vivo	12504004
WIPF1	NCK1	NO	in vitro;in vivo	9694849

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Lyudmila Georgieva[2014]_1	chr2:175365518-175813657 (UCSC build 37, hg19)	448139	2q31.1	deletion

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2q21-q33	chr2:129100000-208200000	1 (0/0/1)
Chr 2	chr2:0-242193529	3 (0/3/0)
2q24-33	chr2:154000000-208200000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr2:174559572..174682916 View in gBrowse