Gene Report

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Basic Info

Approved Symbol	TRPC4AP
Previous Symbol	C20orf188
Symbol Alias	DKFZP727M231, DKFZp586C1223, dJ756N5.2, TRRP4AP, PPP1R158
Approved Name	transient receptor potential cation channel, subfamily C, member 4 associated protein
Previous Name	chromosome 20 open reading frame 188
Name Alias	protein phosphatase 1, regulatory subunit 158
Location	20q11.23
Position	chr20:35002404-35092871, -1
External Links	HGNC: 16181 Entrez Gene: 26133 Ensembl: ENSG00000100991 UCSC: uc002xbk.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Green, E. K.,2012	SNP: rs3818253	BD ImmunoChip:P-value = 0.00000265,OR = 1.333;ImmunoChip, PGC-BD combined data:P-balue = 0.0000000388,OR = 1.164 The SNP showed a significant association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0019902	phosphatase binding	molecular function	IDA[19389623]	9
GO:0016567	protein ubiquitination	biological process	IDA[20551172]; IEA	18
GO:0006511	ubiquitin-dependent protein catabolic process	biological process	IDA[20551172]	5
GO:0034220	ion transmembrane transport	biological process	TAS	50
GO:0070588	calcium ion transmembrane transport	biological process	TAS	24
GO:0005515	protein binding	molecular function	IPI[19389623]	563
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	cellular component	IDA[20551172]	2
GO:0055085	transmembrane transport	biological process	TAS	77

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 8)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TRPC4AP	CHMP4C	NO	yeast 2-hybrid	16730941
TRPC4AP	TRADD	NO	in vitro;in vivo	14585990
TRPC4AP	TNFRSF1A	NO	in vivo	14585990
TRPC4AP	TRAF2	NO	in vitro;in vivo	14585990 , 16876162
TRPC4AP	IKBKG	NO	in vitro	14585990
TRPC4AP	IKBKB	NO	in vitro	14585990
TRPC4AP	CHUK	NO	in vitro;in vivo	14585990
TRPC4AP	RIPK1	NO	in vitro;in vivo	14585990

Related other genetic factors

Gene related SNPs (count: 18)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs3818253	chr20:35009073 - 35009073(1)	intron_variant	2(1/0/1)

rs_ID	Location	Functional Annotation
rs6120819	chr20:35065235 - 35065235(1)	intron_variant
rs6120828	chr20:35086657 - 35086657(1)	intron_variant
rs6087666	chr20:35052439 - 35052439(1)	intron_variant
rs11696652	chr20:35049257 - 35049257(1)	intron_variant
rs6088691	chr20:35045955 - 35045955(1)	intron_variant
rs6088690	chr20:35045523 - 35045523(1)	intron_variant
rs6120812	chr20:35041624 - 35041624(1)	intron_variant
rs6120804	chr20:35035898 - 35035898(1)	intron_variant
rs6088686	chr20:35035634 - 35035634(1)	intron_variant
rs6120799	chr20:35027152 - 35027152(1)	downstream_gene_variant; intron_variant
rs6088678	chr20:35019748 - 35019748(1)	intron_variant
rs6119560	chr20:35019174 - 35019174(1)	intron_variant
rs6120797	chr20:35018199 - 35018199(1)	intron_variant
rs1885117	chr20:35012937 - 35012937(1)	intron_variant
rs6120790	chr20:35011287 - 35011287(1)	intron_variant
rs752448	chr20:35004445 - 35004445(1)	downstream_gene_variant; intron_variant
rs3746435	chr20:34999395 - 34999395(1)	downstream_gene_variant; missense_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 20	chr20:0-64444167	4 (0/3/1)
20p11-q13	chr20:17900000-64444167	1 (1/0/0)
20q11	chr20:28100000-39000000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr20:35002404..35092871 View in gBrowse