Gene Report

Basic Info
Approved Symbol SCN8A
Previous Symbol MED
Symbol Alias Nav1.6, NaCh6, PN4, CerIII
Approved Name sodium channel, voltage gated, type VIII alpha subunit
Previous Name sodium channel, voltage gated, type VIII, alpha polypeptide, "sodium channel, voltage gated, type VIII, alpha subunit"
Location 12q13.1
Position chr12:51590266-51812864, 1
External Links HGNC: 10596
Entrez Gene: 6334
Ensembl: ENSG00000196876
UCSC: uc001ryw.4
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Wang, Y., 2008 SNP: rs1601012, rs303810, rs60637 Two SNPs showed statistically significant differences between bipolar patients and controls in both allele and genotype distribution. Our results indicate that SCN8A may be a potential susceptibility gene for bipolar disorder in the Han Chinese population. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 24)

GO terms by PBA (count: 5)

GO terms by database search (count: 19)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Related other genetic factors
Gene related SNPs (count: 59)

Literature-origin SNPs (count: 3)

LD-proxies (count: 56)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr12:51590266..51812864 View in gBrowse
View in gBrowse