Gene Report

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Basic Info

Approved Symbol	ZDHHC8
Symbol Alias	ZNF378, KIAA1292
Approved Name	zinc finger, DHHC-type containing 8
Location	22q11.21
Position	chr22:20129456-20148007, 1
External Links	HGNC: 18474 Entrez Gene: 29801 Ensembl: ENSG00000099904 UCSC: uc002zrr.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Otani, K.,2005(b)	SNP: rs175170, rs175174 Haplotype: rs175170 - rs175174()	These data suggest that the ZDHHC8 gene may not be associated with susceptibility to BPD or schizophrenia, at least in a Japanese population.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0018345	protein palmitoylation	biological process	IDA[23034182]	1
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005794	Golgi apparatus	cellular component	IDA[16647879]	60
GO:0007626	locomotory behavior	biological process	IEA	23
GO:0030659	cytoplasmic vesicle membrane	cellular component	IEA	12
GO:0008270	zinc ion binding	molecular function	IEA	77
GO:0019706	protein-cysteine S-palmitoyltransferase activity	molecular function	IEA	3
GO:0016409	palmitoyltransferase activity	molecular function	IDA[23034182]	2
GO:0005739	mitochondrion	cellular component	IEA	75

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 5)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs175170	chr22:20133557 - 20133557(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs175174	chr22:20140031 - 20140031(1)	downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs175169	chr22:20129822 - 20129822(1)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs175165	chr22:20128492 - 20128492(1)	downstream_gene_variant; upstream_gene_variant
rs2292570	chr22:20147817 - 20147817(1)	3_prime_UTR_variant; downstream_gene_variant

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Zhang[2009]_306	chr22:17386126-18691917 (Affymetrix SNP 6.0 array reference genome)	1305791		Singleton deletions

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
22q11	chr22:15000000-25500000	1 (0/1/0)
22q11.2	chr22:17400000-25500000	2 (0/2/0)
Chr 22	chr22:0-50818468	2 (0/1/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16150541	These data suggest that the ZDHHC8 gene may not be associated with susceptibility to BPD or schizophrenia, at least in a Japanese population.	Negative

Gene relationship with MDD

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Region: chr22:20129456..20148007 View in gBrowse