Gene Report

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Basic Info

Approved Symbol	GFRA1
Previous Symbol	GDNFRA
Symbol Alias	RETL1, GDNFR, GFR-ALPHA-1, RET1L, TRNR1
Approved Name	GDNF family receptor alpha 1
Location	10q25-q26
Position	chr10:116056925-116273467, -1
External Links	HGNC: 4243 Entrez Gene: 2674 Ensembl: ENSG00000151892 UCSC: uc001lci.3
No. of Studies	2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fallin, M. D.,2005		12 SNP typed, Median D'=0.24, Median r<sup>2</sup> =0.02, 5 LD blocks, 0.44 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in SZ/SZA and all SNP or haplotype P-value > 0.05 in BP.. This gene is suggestive to SZ/SZA , not suggestive to BP.	Negative	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0017. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005102	receptor binding	molecular function	TAS[9545641]	37
GO:0005886	plasma membrane	cellular component	IEA	360
GO:0007411	axon guidance	biological process	TAS	60

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0019898	extrinsic component of membrane	cellular component	TAS[10829012]	8
GO:0031225	anchored component of membrane	cellular component	IEA	11
GO:0007166	cell surface receptor signaling pathway	biological process	NAS[8674117]	23
GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway	biological process	TAS[10829012]	1
GO:0016167	glial cell-derived neurotrophic factor receptor activity	molecular function	TAS[10829012]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
GFRA1	RET	NO	in vivo	10774729
GFRA1	NRTN	NO	in vitro;in vivo	9407096

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 10	chr10:0-133797422	3 (0/2/1)
10q25-q26	chr10:104000000-133797422	2 (0/0/2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16380905	This gene is suggestive to SZ/SZA , not suggestive to BP.	Trend

Gene relationship with MDD

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Region: chr10:116056925..116273467 View in gBrowse