Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	HSP90AA1
Previous Symbol	HSPC1, HSPCA
Symbol Alias	Hsp89, Hsp90, FLJ31884, HSP90N
Approved Name	heat shock protein 90kDa alpha (cytosolic), class A member 1
Previous Name	heat shock 90kD protein 1, alpha, "heat shock 90kDa protein 1, alpha"
Location	14q32.33
Position	chr14:102080738-102139699, -1
External Links	HGNC: 5253 Entrez Gene: 3320 Ensembl: ENSG00000080824 UCSC: uc001ykv.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Drago, A., 2016		Freq(Significant SNPs/total SNPs%)=0.03. Encodes for a is stress induced molecular chaperonen that functions as homodimer. Promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 42)

GO terms by PBA (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045087	innate immune response	biological process	TAS	49
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0005634	nucleus	cellular component	IDA[21630459]	283
GO:0016020	membrane	cellular component	IDA[19946888]	137
GO:0007411	axon guidance	biological process	TAS	60

GO terms by database search (count: 37)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0005576	extracellular region	cellular component	TAS	97
GO:0006898	receptor-mediated endocytosis	biological process	TAS	12
GO:0042026	protein refolding	biological process	TAS[9660753]	2
GO:0030235	nitric-oxide synthase regulator activity	molecular function	IDA[15937123]	4
GO:0000086	G2/M transition of mitotic cell cycle	biological process	TAS	15
GO:0006986	response to unfolded protein	biological process	NAS[2527334]	2
GO:0042470	melanosome	cellular component	IEA	15
GO:0005524	ATP binding	molecular function	TAS[11470816]	118
GO:0005654	nucleoplasm	cellular component	IDA; TAS	163
GO:0000278	mitotic cell cycle	biological process	TAS	33
GO:0071682	endocytic vesicle lumen	cellular component	TAS	4
GO:0007165	signal transduction	biological process	NAS[11470816]	136
GO:0005829	cytosol	cellular component	NAS[12526792]; TAS	223
GO:0005739	mitochondrion	cellular component	IDA[15644312]	75
GO:0044822	poly(A) RNA binding	molecular function	IDA[22658674]	44
GO:0045040	protein import into mitochondrial outer membrane	biological process	IDA[15644312]	1
GO:0030911	TPR domain binding	molecular function	IDA[9660753]; TAS[12526792]	1
GO:0016887	ATPase activity	molecular function	IDA[15937123]	13
GO:0000166	nucleotide binding	molecular function	TAS[11470816]	17
GO:0051131	chaperone-mediated protein complex assembly	biological process	IDA[15644312]	1
GO:1900034	regulation of cellular response to heat	biological process	TAS	10
GO:0006996	organelle organization	biological process	TAS	23
GO:0023026	MHC class II protein complex binding	molecular function	IDA[20458337]	2
GO:0046209	nitric oxide metabolic process	biological process	TAS	5
GO:0006839	mitochondrial transport	biological process	TAS[12526792]	2
GO:0051082	unfolded protein binding	molecular function	IEA	6
GO:0045429	positive regulation of nitric oxide biosynthetic process	biological process	ISS	13
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	biological process	TAS	9
GO:0034605	cellular response to heat	biological process	TAS	11
GO:0005515	protein binding	molecular function	IPI[12176997]	563
GO:0070062	extracellular vesicular exosome	cellular component	IDA[11487543]	176
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0050999	regulation of nitric-oxide synthase activity	biological process	TAS	6
GO:0042802	identical protein binding	molecular function	IPI[16169070]	44
GO:0048010	vascular endothelial growth factor receptor signaling pathway	biological process	TAS	12
GO:0042803	protein homodimerization activity	molecular function	TAS[11470816]	71

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04612	Antigen processing and presentation	7

Gene related BioCarta pathways (count: 8)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 8)

ID	Name	No. of Genes in BDgene
pparaPathway	Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)	12
telPathway	Telomeres, Telomerase, Cellular Aging, and Immortality	4
no1Pathway	Actions of Nitric Oxide in the Heart	9
gcrPathway	Corticosteroids and cardioprotection	9
hifPathway	Hypoxia-Inducible Factor in the Cardiovascular System	3
acrPathway	Ahr Signal Transduction Pathway	2
p53hypoxiaPathway	Hypoxia and p53 in the Cardiovascular system	6
aktPathway	AKT Signaling Pathway	6

Gene related interactors from protein-protein interactions data in HPRD (count: 75)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
HSP90AA1	PRKCD	NO	in vivo	19356729
HSP90AA1	MYC	NO	in vivo	12644583
HSP90AA1	NOS3	YES	in vitro;in vivo;yeast 2-hybrid	11744239 , 12124224 , 11988487
HSP90AA1	CHEK1	YES	in vivo	16330544
HSP90AA1	CSNK2A2	NO	in vitro	7794926
HSP90AA1	MAP3K3	NO	in vitro	14743216
HSP90AA1	TP53	NO	in vivo	11507088 , 12427754
HSP90AA1	TOMM70A	NO	in vitro	12526792
HSP90AA1	UCHL1	NO	in vivo	18550537
HSP90AA1	MAP3K14	NO	in vitro	14743216
HSP90AA1	PDPK1	NO	in vitro;in vivo	11779851
HSP90AA1	PPID	NO	in vitro;yeast 2-hybrid	12145316
HSP90AA1	AKT1	YES	in vivo	10995457 , 19356729
HSP90AA1	AKT2	NO	in vitro;in vivo;yeast 2-hybrid	11988487
HSP90AA1	STUB1	NO	in vitro;in vivo;yeast 2-hybrid	11557750 , 11146632 , 16293251 , 15189447 , 16275660
HSP90AA1	AR	NO	in vitro	1525041
HSP90AA1	IRAK1	NO	in vitro	15647277
HSP90AA1	SRC	NO	in vivo	1310678
HSP90AA1	ASGR1	NO	in vitro;in vivo	12167617
HSP90AA1	PRKCA	NO	in vivo	19356729
HSP90AA1	PTGES3	NO	in vivo	12077419 , 11812147
HSP90AA1	TERT	NO	in vivo	12586360
HSP90AA1	HIF1A	NO	in vitro;in vivo	9079689
HSP90AA1	TNFRSF1A	NO	in vitro	7876093
HSP90AA1	ERBB2	YES	in vivo	11071886
HSP90AA1	PPP5C	NO	in vivo	10400612
HSP90AA1	LSM1	NO	yeast 2-hybrid	15231747
HSP90AA1	BRMS1	NO	in vivo	16919237
HSP90AA1	DAP3	NO	in vitro;in vivo	10903152
HSP90AA1	EIF2AK1	NO	in vitro;in vivo	11036079
HSP90AA1	RPS3A	NO	yeast 2-hybrid	16169070
HSP90AA1	HSPA8	NO	in vivo	9269769
HSP90AA1	MMP2	YES	in vivo	15146192
HSP90AA1	SLC34A1	NO	yeast 2-hybrid	11099500
HSP90AA1	CHUK	NO	in vivo	11864612
HSP90AA1	IKBKG	NO	in vivo	11864612
HSP90AA1	PPARA	NO	in vitro;in vivo	12482853
HSP90AA1	CDC37	NO	in vitro;in vivo	9685350 , 14718169 , 16611982
HSP90AA1	TBK1	NO	in vitro	14743216
HSP90AA1	CRNKL1	NO	in vitro;in vivo	15189447
HSP90AA1	IKBKE	NO	in vivo	14743216
HSP90AA1	STAT3	NO	in vivo	12559950
HSP90AA1	CDC37L1	NO	in vitro	15850399
HSP90AA1	DNAJC7	NO	in vivo;yeast 2-hybrid	15189447
HSP90AA1	NDRG1	NO	in vivo	17220478
HSP90AA1	RIPK1	NO	in vivo	10744744
HSP90AA1	PRKDC	NO	in vitro	2507541
HSP90AA1	BIRC5	NO	in vivo	15894266
HSP90AA1	PIM1	NO	in vitro;in vivo	11237709
HSP90AA1	SMYD3	NO	in vitro;in vivo	15235609
HSP90AA1	ST13	YES	in vitro	9452498
HSP90AA1	MAPK1	NO	in vivo	11748628
HSP90AA1	RUNX1T1	NO	in vitro;in vivo	10076566
HSP90AA1	EPRS	NO	in vitro;in vivo	10913161
HSP90AA1	FKBP6	NO	in vitro;in vivo	19001379
HSP90AA1	MYOD1	NO	in vitro	1406681
HSP90AA1	KDR	NO	in vivo	15247219
HSP90AA1	AHSA1	NO	in vitro;in vivo;yeast 2-hybrid	12504007 , 12604615
HSP90AA1	NR2C2	NO	in vitro	14743216
HSP90AA1	AIP	NO	in vivo	19375531
HSP90AA1	RAF1	NO	in vivo	8408024 , 16093354
HSP90AA1	EIF2AK3	NO	in vivo	12446770
HSP90AA1	PPIL2	NO	in vitro;in vivo	15189447
HSP90AA1	TOMM34	NO	in vitro;yeast 2-hybrid	9660753
HSP90AA1	MS4A2	NO	in vivo	19356729
HSP90AA1	EIF2AK2	NO	in vivo	11447118
HSP90AA1	STIP1	NO	in vitro;in vivo	10786835
HSP90AA1	FAM162A	NO	in vivo;yeast 2-hybrid	16698020
HSP90AA1	IKBKB	NO	in vivo	11864612
HSP90AA1	LCK	NO	in vivo	16888650
HSP90AA1	CALM1	NO	in vitro;in vivo	8486648
HSP90AA1	ERN1	NO	in vivo	12446770
HSP90AA1	SLC2A4	NO	in vivo	16396496
HSP90AA1	WASL	NO	in vitro;in vivo	15791211
HSP90AA1	GUCY1B3	NO	in vitro;in vivo	12676772

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
HSP90AA1_Chr14:101622401		Exonic	1 (0/0/1)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q32	chr14:89300000-107043718	1 (0/1/0)
Chr 14	chr14:0-107043718	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr14:102080738..102139699 View in gBrowse