Gene Report

Basic Info
Approved Symbol PER1
Previous Symbol PER
Symbol Alias RIGUI
Approved Name period circadian clock 1
Previous Name period (Drosophila) homolog 1, "period homolog 1 (Drosophila)"
Location 17p13.1
Position chr17:8140472-8156506, -1
External Links HGNC: 8845
Entrez Gene: 5187
Ensembl: ENSG00000179094
UCSC: uc002gkd.3
No. of Studies 5 (Positive: 2; Negative: 3; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 5)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Mansour, H. A., 2006 Significant association was detected (P<0.05) with Pittsburgh BD1 using CC test, but no significant association was detected in BD1 using TDT test. Positive Comment on Study
Mansour, H. A.,2009 Gene-based tests:X<sup>2</sup>=4.005, P-value = 0.111 in recessive model, X<sup>2</sup>=0.81, P-value = 0.544 in dominant model, X<sup>2</sup>=0.15, P-value = 0.893 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. Negative Comment on Study
Nievergelt, C. M., 2006 Single SNP TDT analyses showed no evidence for association to BPAD. Negative Comment on Study
Kripke, D. F.,2009 SNP: rs2585405 Significant association was observed in the BP group. Positive Comment on Study
Byrne, E. M., 2014 P-value=0.15. Gene-based tests show no significant association between this gene and BD. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 33)

GO terms by PBA (count: 2)

GO terms by database search (count: 31)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

Gene related interactors from protein-protein interactions data in HPRD (count: 7)

Related other genetic factors
Gene related SNPs (count: 4)

Literature-origin SNPs (count: 2)

LD-proxies (count: 2)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 3)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr17:8140472..8156506 View in gBrowse
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