Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	GNAI2
Previous Symbol	GNAI2B
Symbol Alias	GIP
Approved Name	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
Name Alias	GTP-binding regulatory protein Gi alpha-2 chain
Location	3p21.31
Position	chr3:50226292-50259355, 1
External Links	HGNC: 4385 Entrez Gene: 2771 Ensembl: ENSG00000114353 UCSC: uc003cyq.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
McDonald, M. L.,2012	SNP: rs2282751	None of the association tests of the tagSNPs with either BPD I or BPD II reached genome-wide significance (P < 5E-08).	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 38)

GO terms by PBA (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007268	synaptic transmission	biological process	TAS	116
GO:0016020	membrane	cellular component	IDA[19946888]	137
GO:0007194	negative regulation of adenylate cyclase activity	biological process	TAS[9637720]	11
GO:0005886	plasma membrane	cellular component	IDA; TAS	360
GO:0004871	signal transducer activity	molecular function	IBA	32

GO terms by database search (count: 33)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005834	heterotrimeric G-protein complex	cellular component	IBA	6
GO:0005829	cytosol	cellular component	IEA	223
GO:0030168	platelet activation	biological process	TAS	22
GO:0045121	membrane raft	cellular component	IEA	22
GO:0008284	positive regulation of cell proliferation	biological process	IEA	44
GO:0031982	vesicle	cellular component	IDA[24769233]	20
GO:0001973	adenosine receptor signaling pathway	biological process	IBA	2
GO:0051924	regulation of calcium ion transport	biological process	IEA	8
GO:0005813	centrosome	cellular component	IDA[17635935]	34
GO:0030496	midbody	cellular component	IDA[17635935]	8
GO:0035556	intracellular signal transduction	biological process	IEA	38
GO:0005515	protein binding	molecular function	IPI[16189514]	563
GO:0005525	GTP binding	molecular function	IEA	20
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	biological process	IBA; TAS	10
GO:0070062	extracellular vesicular exosome	cellular component	IDA[12519789]	176
GO:0008152	metabolic process	biological process	IBA; IEA; TAS[9637720]	50
GO:0007584	response to nutrient	biological process	TAS[8587610]	10
GO:0003924	GTPase activity	molecular function	IBA	14
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[8587610]	64
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway	biological process	IEA	6
GO:0050805	negative regulation of synaptic transmission	biological process	IEA	2
GO:0007165	signal transduction	biological process	TAS[7961880]	136
GO:0007596	blood coagulation	biological process	TAS	44
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0000186	activation of MAPKK activity	biological process	IEA	6
GO:0001664	G-protein coupled receptor binding	molecular function	IBA	9
GO:0031683	G-protein beta/gamma-subunit complex binding	molecular function	IBA	6
GO:0008283	cell proliferation	biological process	IEA	37
GO:0051301	cell division	biological process	IMP[17635935]	20
GO:0007214	gamma-aminobutyric acid signaling pathway	biological process	IBA	15
GO:0007049	cell cycle	biological process	IEA	6
GO:0005654	nucleoplasm	cellular component	IDA	163

Gene related KEGG pathways (count: 6)

KEGG pathways by PBA (count: 3)

ID	Name	No. of Genes in BDgene
hsa04530	Tight junction	18
hsa04540	Gap junction	15
hsa04730	Long-term depression	15

KEGG pathways by database search (count: 3)

ID	Name	No. of Genes in BDgene
hsa04670	Leukocyte transendothelial migration	13
hsa04360	Axon guidance	16
hsa04916	Melanogenesis	16

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 42)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
GNAI2	F2R	NO	in vitro;in vivo	10644723 , 8982657
GNAI2	OPRM1	NO	in vivo	12068084
GNAI2	NUCB1	NO	in vitro;yeast 2-hybrid	9647645
GNAI2	TUBA4A	NO	yeast 2-hybrid	16169070
GNAI2	RASD1	NO	in vitro	10471929 , 10840027
GNAI2	RIC8A	NO	in vitro;yeast 2-hybrid	12509430
GNAI2	RGS19	NO	in vitro;yeast 2-hybrid	8986788
GNAI2	ADORA1	NO	in vivo	11369591
GNAI2	TTC1	NO	in vitro	12748287
GNAI2	LPAR3	YES	in vivo	10727522
GNAI2	EYA1	NO	in vitro;yeast 2-hybrid	11950062
GNAI2	NGB	NO	in vitro	12860983
GNAI2	RGS18	NO	in vitro	11955952
GNAI2	RGS14	NO	in vitro;yeast 2-hybrid	11387333
GNAI2	C5AR1	NO	in vitro	7962171
GNAI2	CCR5	NO	in vivo	15251452
GNAI2	CXCR2	NO	in vivo	8662698
GNAI2	EDNRA	NO	in vivo	7882989
GNAI2	DRD2	YES	in vivo	10978845
GNAI2	PLSCR1	NO	yeast 2-hybrid	16189514
GNAI2	P2RY12	NO	in vivo	8554519
GNAI2	ADRA2B	NO	in vivo	2169434
GNAI2	OPRD1	NO	in vivo	1671672
GNAI2	CXCR1	NO	in vitro;in vivo	8662698 , 8903513
GNAI2	CAV1	NO	in vitro	8621645
GNAI2	PTPRU	NO	in vitro;in vivo	16298104
GNAI2	RGS16	NO	in vitro	14634662 , 9079700
GNAI2	CNR1	YES	in vivo	11168387
GNAI2	MDFI	NO	yeast 2-hybrid	16189514
GNAI2	MTNR1A	YES	in vivo	10598579 , 17215244
GNAI2	EYA2	NO	in vitro;yeast 2-hybrid	10906137
GNAI2	IGF1R	NO	in vivo	11120746
GNAI2	GPSM2	NO	in vitro;yeast 2-hybrid	8973305
GNAI2	FPR1	NO	in vivo	8663057
GNAI2	ADCY1	YES	in vivo	2121366
GNAI2	IL8	NO	in vivo	8662698
GNAI2	LHB	NO	in vitro	8663226
GNAI2	LHCGR	NO	in vivo	10493819
GNAI2	RGS12	YES	in vitro;yeast 2-hybrid	11387333
GNAI2	MTNR1B	NO	in vivo	17215244
GNAI2	RGS5	YES	in vitro	9079700
GNAI2	AGTR2	NO	in vitro	8663053 , 11055978

Related other genetic factors

Gene related SNPs (count: 2)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2282751	chr3:50254353 - 50254353(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)

LD-proxies (count: 1)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs4141060		chr3:50262685 - 50262685(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)
3p21	chr3:43600000-54400000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr3:50226292..50259355 View in gBrowse