Gene Report

Basic Info
Approved Symbol KCNH7
Symbol Alias Kv11.3, HERG3, erg3
Approved Name potassium channel, voltage gated eag related subfamily H, member 7
Previous Name potassium voltage-gated channel, subfamily H (eag-related), member 7
Location 2q24.3
Position chr2:162371407-162838730, -1
External Links HGNC: 18863
Entrez Gene: 90134
Ensembl: ENSG00000184611
UCSC: uc002uch.2
No. of Studies 3 (Positive: 2; Negative: 0; trend: 1)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Kuo, P. H., 2014 SNP: rs6736615 Gene-based P-value (allelic model) =0.0573, P-value (additive model) =0.0047. KCNH7, a gene associated with voltage-gated potassium channels (P= 0.0047) Positive Comment on Study
Strauss, K. A., 2014 SNP: rs78247304 This gene has the only candidate allele shared among them. Positive Comment on Study
Georgi, B., 2014 SNP: rs78247304 Amish-specific putative damaging exonic missense variant was found within this gene. Trend Comment on Study
Gene functional annotation
Gene related GO terms (count: 12)

GO terms by PBA (count: 5)

GO terms by database search (count: 7)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 26)

Literature-origin SNPs (count: 3)

LD-proxies (count: 23)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr2:162371407..162838730 View in gBrowse
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