Gene Report

Basic Info
Approved Symbol MTHFD1
Previous Symbol MTHFC, MTHFD
Approved Name methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
Location 14q24
Position chr14:64388031-64463457, 1
External Links HGNC: 7432
Entrez Gene: 4522
Ensembl: ENSG00000100714
UCSC: uc001xhb.3
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Kempisty, B., 2007 (b) Other variant: MTHFD_G1958A MTHFD1 1958AA or 1958AG genotypes are linked to BDI Positive Comment on Study
Yosifova, A.,2009 SNP: rs2236225 No SNP of this gene had significant association with BD in our population. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 20)

GO terms by PBA (count: 1)

GO terms by database search (count: 19)

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 2)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 4)

Literature-origin SNPs (count: 1)

LD-proxies (count: 3)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr14:64388031..64463457 View in gBrowse
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