Gene Report

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Basic Info

Approved Symbol	HCAR3
Previous Symbol	GPR109B
Symbol Alias	HCA3, HM74
Approved Name	hydroxycarboxylic acid receptor 3
Previous Name	G protein-coupled receptor 109B
Location	12q24.31
Position	chr12:122714756-122716892, -1
External Links	HGNC: 16824 Entrez Gene: 8843 Ensembl: ENSG00000255398 UCSC: uc001ucy.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Shink, E.,2005(a)	Other variant: HM74_GC10E01A, HM74_GC10E01B, HM74_GC10E01C, HM74_GC10E01D, HM74_GC10E01E	We found no polymorphisms associated with bipolar disorder in this gene.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005887	integral component of plasma membrane	cellular component	TAS[7505609]	158
GO:0005886	plasma membrane	cellular component	TAS	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IEA	64
GO:0004930	G-protein coupled receptor activity	molecular function	IEA	26

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 5)

Variant Name	Variant Type	No. of Studies (Positive/Negative/Trend)
HM74_GC10E01A	point mutation	1 (0/1/0)
HM74_GC10E01D	point mutation	1 (0/1/0)
HM74_GC10E01E	point mutation	1 (0/1/0)
HM74_GC10E01B	point mutation	1 (0/1/0)
HM74_GC10E01C	point mutation	1 (0/1/0)

Gene related regions (count: 6)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
12q24.3	chr12:120300000-133275309	1 (1/0/0)
Chr 12	chr12:0-133275309	3 (0/3/0)
12q24	chr12:108600000-133275309	4 (1/1/2)
12q23-q24	chr12:95800000-133275309	3 (2/0/1)
12q24.31	chr12:120300000-125400000	1 (1/0/0)
12q	chr12:38200000-133851895	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr12:122714756..122716892 View in gBrowse