Gene Report

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Basic Info

Approved Symbol	HS6ST2
Approved Name	heparan sulfate 6-O-sulfotransferase 2
Location	Xq26.2
Position	chrX:132626016-132961395, -1
External Links	HGNC: 19133 Entrez Gene: 90161 Ensembl: ENSG00000171004 UCSC: uc011mvd.1
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Jamain, S., 2014	SNP: rs5930575	It showed nominal evidence for association with BD.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0009405	pathogenesis	biological process	TAS	13
GO:0006024	glycosaminoglycan biosynthetic process	biological process	TAS	3
GO:0017095	heparan sulfate 6-O-sulfotransferase activity	molecular function	IEA	1
GO:0030203	glycosaminoglycan metabolic process	biological process	TAS	5
GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification	biological process	IEA	1
GO:0005975	carbohydrate metabolic process	biological process	TAS	12
GO:0000139	Golgi membrane	cellular component	TAS	36
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa01030	Glycan structures - biosynthesis 1	8
hsa00534	Heparan sulfate biosynthesis	3

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs5930575	chrX:132675341 - 132675341(1)	intron_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Xq24-q27.1	chrX:117400000-141200000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chrX:132626016..132961395 View in gBrowse