Gene Report

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Basic Info

Approved Symbol	CAP2
Approved Name	CAP, adenylate cyclase-associated protein, 2 (yeast)
Location	6p22.3
Position	chr6:17393216-17557792, 1
External Links	HGNC: 20039 Entrez Gene: 10486 Ensembl: ENSG00000112186 UCSC: uc003ncb.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Goossens, D.,2000	Other variant: CAP2_triplet repeat	Comparison of the allele and genotype distribution of the CAP2 repeat between BP cases and controls using Genepop did not reveal significant differences.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IEA	360
GO:0003779	actin binding	molecular function	IEA	24
GO:0007411	axon guidance	biological process	TAS	60

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007163	establishment or maintenance of cell polarity	biological process	TAS[7962207]	5
GO:0007190	activation of adenylate cyclase activity	biological process	TAS[7962207]	12
GO:0007010	cytoskeleton organization	biological process	IEA	11
GO:0007165	signal transduction	biological process	TAS[7962207]	136
GO:0005515	protein binding	molecular function	IPI[25416956]	563

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CAP2	ACTG1	NO	in vivo	8761950
CAP2	PRPF40A	NO	yeast 2-hybrid	15231748
CAP2	CAP1	NO	in vivo;yeast 2-hybrid	8761950

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
CAP2_triplet repeat	microsatellite		1 (0/1/0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6p22	chr6:15200000-30500000	1 (0/1/0)
6p22.3	chr6:15200000-25200000	1 (0/1/0)
6p23-p21.1	chr6:13400000-46200000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	ID in SZGene	Result Category
19694819	803	Negative

Gene relationship with MDD

Reference	Description	Category in MDD	Link in MK4MDD
15303102	Genes altered in major depressive disorder	Pos	CAP2

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Region: chr6:17393216..17557792 View in gBrowse