BDgene

Gene Report

Basic Info
Approved Symbol ARHGEF5
Symbol Alias TIM, TIM1, GEF5, P60
Approved Name Rho guanine nucleotide exchange factor (GEF) 5
Name Alias transforming immortalized mammary oncogene, "guanine nucleotide regulatory protein TIM"
Location 7q35
Position chr7:144355288-144380632, 1
External Links HGNC: 13209
Entrez Gene: 7984
Ensembl: ENSG00000050327
UCSC: uc003wel.3
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Dmitrzak-Weglarz, M. P., 2014 SNP: rs2291739, rs11171856 We found significant association between one TIM SNP and both BPDII and UPD. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 9)

GO terms by PBA (count: 1)

GO terms by database search (count: 8)


Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 3)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 3)


Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Related other genetic factors
Gene related SNPs (count: 2)

Literature-origin SNPs (count: 2)

LD-proxies (count: 0)


Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr7:144355288..144380632 View in gBrowse
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