Gene Report

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Basic Info

Approved Symbol	SSTR1
Approved Name	somatostatin receptor 1
Location	14q13
Position	chr14:38207999-38213067, 1
External Links	HGNC: 11330 Entrez Gene: 6751 Ensembl: ENSG00000139874 UCSC: uc001wul.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gratacos, M.,2009	SNP: rs2250334	Nominal associations with bipolar disorder was observed.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0005887	integral component of plasma membrane	cellular component	TAS[1346068]	158
GO:0007268	synaptic transmission	biological process	IBA	116
GO:0007586	digestion	biological process	TAS[1346068]	6
GO:0042923	neuropeptide binding	molecular function	IBA	2

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007283	spermatogenesis	biological process	IEA	29
GO:0071392	cellular response to estradiol stimulus	biological process	IBA	8
GO:0030900	forebrain development	biological process	IEA	5
GO:0038170	somatostatin signaling pathway	biological process	IBA	2
GO:0042594	response to starvation	biological process	IEA	8
GO:0004994	somatostatin receptor activity	molecular function	IDA[1346068]	2
GO:0007267	cell-cell signaling	biological process	TAS[1346068]	29
GO:0043005	neuron projection	cellular component	IBA	38
GO:0007584	response to nutrient	biological process	TAS[1346068]	10
GO:0007218	neuropeptide signaling pathway	biological process	IBA	18
GO:0007215	glutamate receptor signaling pathway	biological process	IEA	7
GO:0021549	cerebellum development	biological process	IEA	3
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	TAS[8405411]	17
GO:0007166	cell surface receptor signaling pathway	biological process	TAS[1346068]	23
GO:0008285	negative regulation of cell proliferation	biological process	TAS[9886848]	41

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
SSTR1	PRMT5	NO	in vitro;in vivo;yeast 2-hybrid	10734105
SSTR1	SSTR5	YES	in vitro	10713101
SSTR1	CORT	NO	in vivo	9205124 , 9125122

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2250334	chr14:38199788 - 38199788(1)	intron_variant; non_coding_transcript_variant	1(1/0/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs4073844		chr14:38208330 - 38208330(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 6)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q21	chr14:37400000-50400000	3 (2/0/1)
14q13.2-21.3	chr14:34800000-50400000	1 (0/1/0)
Chr 14	chr14:0-107043718	2 (0/2/0)
14q12-q22.3	chr14:24100000-57600000	1 (1/0/0)
14q13.1-21.1	chr14:32900000-43000000	1 (0/1/0)
14q13.1-q24.1	chr14:32900000-69800000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr14:38207999..38213067 View in gBrowse