Gene Report

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Basic Info

Approved Symbol	SVIL
Approved Name	supervillin
Name Alias	archvillin
Location	10p11.2
Position	chr10:29457338-29736781, -1
External Links	HGNC: 11480 Entrez Gene: 6840 Ensembl: ENSG00000197321 UCSC: uc001iut.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs12773173	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA[12711699]	283
GO:0005886	plasma membrane	cellular component	IDA	360
GO:0051015	actin filament binding	molecular function	IDA[12711699]	9

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0030496	midbody	cellular component	ISS	8
GO:0005515	protein binding	molecular function	IPI[18639526]	563
GO:0043034	costamere	cellular component	IDA[12711699]	4
GO:0071437	invadopodium	cellular component	IEA	1
GO:0032154	cleavage furrow	cellular component	ISS	2
GO:0007519	skeletal muscle tissue development	biological process	IMP[12711699]	6
GO:0032467	positive regulation of cytokinesis	biological process	ISS	8
GO:0036449	microtubule minus-end	cellular component	ISS	1
GO:0002102	podosome	cellular component	IEA	3
GO:0005925	focal adhesion	cellular component	IDA[21423176]	32
GO:0015629	actin cytoskeleton	cellular component	IDA; NAS[9867483]	18
GO:0007010	cytoskeleton organization	biological process	IEA	11

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 62)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
SVIL	AMOTL2	NO	Y2H	16880273
SVIL	GLIPR2	NO	VV	12202484
SVIL	ITGB3BP	NO	Y2H	20309963
SVIL	TNFAIP1	NO	VV;Y2H	20309963
SVIL	ACTB	NO	VV	12202484
SVIL	LMNA	NO	Y2H	20309963
SVIL	MYLK	NO	VT	17925381
SVIL	CTBP2	YES	Y2H	16880273
SVIL	LIMA1	NO	VT;VV;Y2H	20309963
SVIL	MAD1L1	YES	Y2H	16880273
SVIL	GNAI2	YES	VV	12202484
SVIL	FLOT2	NO	VV	12202484
SVIL	KRT18	NO	Y2H	20309963
SVIL	PAN3	NO	Y2H	20309963
SVIL	YWHAG	NO	in vivo	15324660
SVIL	NME2	NO	Y2H	20309963
SVIL	UXT	NO	Y2H	20309963
SVIL	GNB2	NO	VV	12202484
SVIL	HAX1	NO	VV;Y2H	20309963
SVIL	ATRX	NO	Y2H	20309963
SVIL	TGFB1I1	NO	in vivo	11792840
SVIL	MMP25	NO	VV	12202484
SVIL	FLNA	NO	VV;Y2H	20309963
SVIL	CAMP	NO	VV	12202484
SVIL	MIF4GD	NO	VV;Y2H	20309963
SVIL	TRIP6	NO	Y2H	16880273
SVIL	BUB1	NO	VV;Y2H	20309963
SVIL	MLL	NO	Y2H	20309963
SVIL	KIF4A	NO	Y2H	16880273
SVIL	CAV3	YES	VV	12711699
SVIL	FLOT1	YES	VV	12202484
SVIL	ACTN4	NO	VV	12202484
SVIL	MYO1G	NO	VV	12202484
SVIL	CENPF	NO	Y2H	20309963
SVIL	ODF2	NO	VV;Y2H	20309963
SVIL	CLTC	YES	VV	12202484
SVIL	LUC7L2	NO	yeast 2-hybrid	16169070
SVIL	MYH10	NO	VT;VV	17925381
SVIL	HMMR	NO	VV;Y2H	20309963
SVIL	KIF22	NO	Y2H	20309963
SVIL	SPTBN1	NO	VV	12202484
SVIL	KIF14	NO	VT;VV;Y2H	20309963
SVIL	SH3PXD2A	YES	VV;Y2H	20309963
SVIL	MYH9	NO	VT	17925381
SVIL	NEB	NO	VV;Vt;Y2H	18639526
SVIL	HSPA5	YES	Y2H	16880273
SVIL	STOM	NO	VV	12202484
SVIL	DYNLT1	NO	Y2H	16880273
SVIL	P2RX7	YES	in vivo	11707406
SVIL	MKL2	YES	Y2H	20309963
SVIL	VIM	NO	VV	12202484
SVIL	KIFC3	NO	VV;Y2H	20309963
SVIL	AR	NO	in vitro;yeast 2-hybrid	11792840
SVIL	CTTN	YES	VT;VV	19109420
SVIL	LPP	NO	Y2H	16880273
SVIL	HSP90AA1	YES	Y2H	20309963
SVIL	GPSM3	NO	VV	12202484
SVIL	ACTN1	NO	VV	12202484
SVIL	LMNB2	NO	Y2H	20309963
SVIL	GOLGA2	NO	Y2H	16880273
SVIL	MPHOSPH9	NO	Y2H	20309963
SVIL	SPTAN1	NO	VV	12202484

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs12773173	chr10:29722375 - 29722375(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
10p11-p14	chr10:6600000-39800000	1 (0/1/0)
Chr 10	chr10:0-133797422	3 (0/2/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr10:29457338..29736781 View in gBrowse