Gene Report

Approved Symbol	ARNTL
Symbol Alias	MOP3, JAP3, BMAL1, PASD3, bHLHe5
Approved Name	aryl hydrocarbon receptor nuclear translocator-like
Location	11p15
Position	chr11:13276652-13387266, 1
External Links	HGNC: 701 Entrez Gene: 406 Ensembl: ENSG00000133794 UCSC: uc001mkp.3
No. of Studies	7 (Positive: 5; Negative: 2; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Soria, V.,2010	SNP: rs11022778, rs17452383, rs1982350, rs2278749, rs2279287, rs3789327, rs900144, rs969485, rs969486	Significant associations of ARNTL gene were found in BPD patients.	Positive	Comment on Study
Yosifova, A.,2009	SNP: rs1982350, rs2278749, rs3789327	No SNP of this gene had significant association with BD in our population.	Negative	Comment on Study
Nievergelt, C. M., 2006	Haplotype: rs3789327 - rs2278749(A-T)	Single SNP TDT analyses showed no evidence for association to BPAD. Haplotypes in ARNTL and PER3 were found to be significantly associated with BPAD via single-gene permutation tests.	Positive	Comment on Study
Mansour, H. A., 2006	SNP: rs1481892, rs1982350, rs2278749, rs2279287, rs2290035, rs2896635, rs4757142, rs7107287, rs895682, rs969486 Haplotype: rs1982350 - rs2896635 - rs2278749 - rs969486 - rs2290035()	Significant association was detected (P<0.05) with Pittsburgh BD1 using CC test and BD1 using TDT test.	Positive	Comment on Study
Byrne, E. M., 2014		P-value=0.26. Gene-based tests show no significant association between this gene and BD.	Negative	Comment on Study
Dmitrzak-Weglarz, M. P., 2014	SNP: rs7947951, rs3816360, rs3789327, rs11600996, rs11022780 Haplotype: rs11824092 - rs1982350(C-G), rs11824092 - rs1982350(T-A), rs11824092 - rs1982350(C-A), rs11600996 - rs11022779 - rs11022780(C-G-T), rs11600996 - rs11022779 - rs11022780(T-G-C), rs11600996 - rs11022779 - rs11022780(T-A-C), rs3789327 - rs11022778(A-T), rs3789327 - rs11022778(G-G), rs3789327 - rs11022778(G-T)	We detected ARNTL haplotype variant (rs1160996C/rs11022779G/rs1122780T) to be associated with increased risk of MD, BPD (both types).	Positive	Comment on Study
Mansour, H. A.,2009	SNP: rs7126303	Gene-based tests:X<sup>2</sup>=4.293, P-value = 0.422 in additive model, X<sup>2</sup>=4.05, P-value = 0.566 in dominant model, X<sup>2</sup>=2.854, P-value = 0.8 in recessive model in BPI. Association was observed using single SNP-based analyses while no association was observed using gene-based tests in BPI.	Positive	Comment on Study

Region: chr11:13276652..13387266 View in gBrowse