Gene Report

Basic Info
Approved Symbol ARNTL
Symbol Alias MOP3, JAP3, BMAL1, PASD3, bHLHe5
Approved Name aryl hydrocarbon receptor nuclear translocator-like
Location 11p15
Position chr11:13276652-13387266, 1
External Links HGNC: 701
Entrez Gene: 406
Ensembl: ENSG00000133794
UCSC: uc001mkp.3
No. of Studies 7 (Positive: 5; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 7)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Soria, V.,2010 SNP: rs11022778, rs17452383, rs1982350, rs2278749, rs2279287, rs3789327, rs900144, rs969485, rs969486 Significant associations of ARNTL gene were found in BPD patients. Positive Comment on Study
Yosifova, A.,2009 SNP: rs1982350, rs2278749, rs3789327 No SNP of this gene had significant association with BD in our population. Negative Comment on Study
Nievergelt, C. M., 2006 Haplotype: rs3789327 - rs2278749(A-T) Single SNP TDT analyses showed no evidence for association to BPAD. Haplotypes in ARNTL and PER3 were found to be significantly associated with BPAD via single-gene permutation tests. Positive Comment on Study
Mansour, H. A., 2006 SNP: rs1481892, rs1982350, rs2278749, rs2279287, rs2290035, rs2896635, rs4757142, rs7107287, rs895682, rs969486
Haplotype: rs1982350 - rs2896635 - rs2278749 - rs969486 - rs2290035()
Significant association was detected (P<0.05) with Pittsburgh BD1 using CC test and BD1 using TDT test. Positive Comment on Study
Byrne, E. M., 2014 P-value=0.26. Gene-based tests show no significant association between this gene and BD. Negative Comment on Study
Dmitrzak-Weglarz, M. P., 2014 SNP: rs7947951, rs3816360, rs3789327, rs11600996, rs11022780
Haplotype: rs11824092 - rs1982350(C-G), rs11824092 - rs1982350(T-A), rs11824092 - rs1982350(C-A), rs11600996 - rs11022779 - rs11022780(C-G-T), rs11600996 - rs11022779 - rs11022780(T-G-C), rs11600996 - rs11022779 - rs11022780(T-A-C), rs3789327 - rs11022778(A-T), rs3789327 - rs11022778(G-G), rs3789327 - rs11022778(G-T)
We detected ARNTL haplotype variant (rs1160996C/rs11022779G/rs1122780T) to be associated with increased risk of MD, BPD (both types). Positive Comment on Study
Mansour, H. A.,2009 SNP: rs7126303 Gene-based tests:X<sup>2</sup>=4.293, P-value = 0.422 in additive model, X<sup>2</sup>=4.05, P-value = 0.566 in dominant model, X<sup>2</sup>=2.854, P-value = 0.8 in recessive model in BPI. Association was observed using single SNP-based analyses while no association was observed using gene-based tests in BPI. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 44)

GO terms by PBA (count: 4)

GO terms by database search (count: 40)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

Gene related interactors from protein-protein interactions data in HPRD (count: 8)

Related other genetic factors
Gene related SNPs (count: 73)

Literature-origin SNPs (count: 20)

LD-proxies (count: 53)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 3)

Overlap with SZ from candidate gene intersection analysis (count: 3)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 2)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr11:13276652..13387266 View in gBrowse
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