Gene Report

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Basic Info

Approved Symbol	AHRR
Previous Symbol	AHH, AHHR
Symbol Alias	KIAA1234, bHLHe77
Approved Name	aryl-hydrocarbon receptor repressor
Previous Name	aryl hydrocarbon receptor regulator
Location	5p15.33
Position	chr5:304176-438291, 1
External Links	HGNC: 346 Entrez Gene: 57491 Ensembl: ENSG00000063438 UCSC: uc003jaw.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Noor A., 2014		Selected stringent CNV related to this gene is validated by qPCR from BD case data.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004871	signal transducer activity	molecular function	IEA	32
GO:0003677	DNA binding	molecular function	IEA	83

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007165	signal transduction	biological process	IEA	136
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0033235	positive regulation of protein sumoylation	biological process	IEA	2
GO:0009410	response to xenobiotic stimulus	biological process	IBA	2
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IBA	91
GO:0034753	nuclear aryl hydrocarbon receptor complex	cellular component	IBA	2
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IBA	62
GO:0046983	protein dimerization activity	molecular function	IEA	19
GO:0001191	RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	molecular function	IBA	3

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
AHRR	ARNT	NO	in vitro;in vivo;yeast 2-hybrid	9887096

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Abdul Noor[2014]_7	chr5:409381-706343 (NCBI Build 36/hg18)	297000	5p15.33	duplication

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 5	chr5:0-181538259	3 (0/2/1)
5p15.33	chr5:0-4400000	1 (0/0/1)
5pter-p15.1	chr5:0-18400000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr5:304176..438291 View in gBrowse