Gene Report

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Basic Info

Approved Symbol	SEMG2
Symbol Alias	SGII
Approved Name	semenogelin II
Name Alias	Semenogelin 2
Location	20q12-q13.1
Position	chr20:45221300-45224458, 1
External Links	HGNC: 10743 Entrez Gene: 6407 Ensembl: ENSG00000124157 UCSC: uc002xnk.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BD:Smallest P-value per gene=0.00849, Product of P truncation <=0.01=0.00849, Product of P truncation <=0.001=NA. It showed evidence for association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA[21630459]	283
GO:0005198	structural molecule activity	molecular function	IEA	14

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005615	extracellular space	cellular component	TAS[1517240]	85
GO:0030141	secretory granule	cellular component	IEA	14
GO:0019953	sexual reproduction	biological process	IEA	1
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23533145]	176

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 7)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
SEMG2	KLK2	NO	in vitro;in vivo	10411640
SEMG2	PRKAR2A	NO	in vitro;in vivo	12399526
SEMG2	SEMG1	NO	in vitro	9523691
SEMG2	TGM1	NO	in vitro	9523691
SEMG2	KLK3	NO	in vitro	11027412
SEMG2	SERPINA5	NO	in vitro	8665956
SEMG2	PRKCA	NO	in vitro;in vivo	12399526

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 20	chr20:0-64444167	4 (0/3/1)
20p11-q13	chr20:17900000-64444167	1 (1/0/0)
20q13	chr20:43100000-64444167	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19065143	In SZ:Smallest P-value per gene=0.00387, Product of P truncation <=0.01=0.00387, Product of P truncation <=0.001=NA It showed evidence for association with SZ.	Positive

Gene relationship with MDD

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Region: chr20:45221300..45224458 View in gBrowse