Gene Report

Basic Info
Approved Symbol TNF
Previous Symbol TNFA
Symbol Alias TNFSF2, DIF, TNF-alpha
Approved Name tumor necrosis factor
Previous Name tumor necrosis factor (TNF superfamily, member 2)
Name Alias TNF superfamily, member 2
Location 6p21.3
Position chr6:31575567-31578336, 1
External Links HGNC: 11892
Entrez Gene: 7124
Ensembl: ENSG00000232810
UCSC: uc003nui.4
No. of Studies 4 (Positive: 2; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 4)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Clerici, M.,2009 Other variant: TNF-alpha_308G/A Our data reported a different genotype and allele distribution of -308 TNF-α and +874 IFN-γ in the bipolar II group that showed a higher percentage of subjects characterized by a lower production of both cytokines. Positive Comment on Study
Yosifova, A.,2009 SNP: rs1800629 No SNP of this gene had significant association with BD in our population. Negative Comment on Study
Meira-Lima, I.,2003(b) Other variant: TNF_-G308A The TNF-a gene variant did not present a significant difference in the allele and genotype distribution between the BPAD and the control groups. Negative Comment on Study
Pae, C. U.,2004(a) Other variant: TNF_-G308A The -G308A TNF-alpha gene polymorphism may confer a risk for BID in the Korean population. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 130)

GO terms by PBA (count: 5)

GO terms by database search (count: 125)

Gene related KEGG pathways (count: 18)

Gene related BioCarta pathways (count: 21)

Gene related interactors from protein-protein interactions data in HPRD (count: 12)

Related other genetic factors
Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 21)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 6)

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Region: chr6:31575567..31578336 View in gBrowse
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