Gene Report

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Basic Info

Approved Symbol	PTPRZ1
Previous Symbol	PTPZ, PTPRZ
Symbol Alias	PTP18, RPTPB, phosphacan
Approved Name	protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Location	7q31.3
Position	chr7:121873089-122062036, 1
External Links	HGNC: 9685 Entrez Gene: 5803 Ensembl: ENSG00000106278 UCSC: uc003vjy.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Chen, X., 2015		PTPRZ1 has been implicated in BPD, SCZ and alcoholism.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	molecular function	TAS[1323835]	5
GO:0005887	integral component of plasma membrane	cellular component	TAS[8387522]	158
GO:0007417	central nervous system development	biological process	TAS[8387522]	21

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006470	protein dephosphorylation	biological process	TAS[1323835]	10
GO:0072534	perineuronal net	cellular component	IEA	2
GO:0070445	regulation of oligodendrocyte progenitor proliferation	biological process	ISS	2
GO:0004725	protein tyrosine phosphatase activity	molecular function	ISS	6
GO:0002244	hematopoietic progenitor cell differentiation	biological process	IEA	6
GO:0005578	proteinaceous extracellular matrix	cellular component	IEA	19
GO:0007409	axonogenesis	biological process	IEA	11
GO:0005515	protein binding	molecular function	IPI[17681947]	563
GO:0007611	learning or memory	biological process	ISS	13
GO:0048709	oligodendrocyte differentiation	biological process	ISS	5
GO:0035335	peptidyl-tyrosine dephosphorylation	biological process	ISS	9

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	11

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 7)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PTPRZ1	GRLF1	NO	in vitro	16513268
PTPRZ1	ALK	NO	in vitro;in vivo	17681947
PTPRZ1	ADD2	NO	in vivo	16105548
PTPRZ1	PTN	NO	in vitro;in vivo	10706604 , 16814777
PTPRZ1	GIT1	NO	in vivo;yeast 2-hybrid	11381105
PTPRZ1	MDK	YES	in vitro;in vivo	10212223
PTPRZ1	CTNNB1	NO	in vivo	10706604

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7q31.3	chr7:117700000-127500000	0
7q31.32	chr7:121400000-124100000	1 (0/0/1)
7q21-31	chr7:77900000-127500000	1 (1/0/0)
Chr 7	chr7:0-159345973	3 (0/3/0)
7q31-33	chr7:107800000-138500000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr7:121873089..122062036 View in gBrowse