Gene Report

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Basic Info

Approved Symbol	DOCK3
Symbol Alias	KIAA0299, MOCA, PBP
Approved Name	dedicator of cytokinesis 3
Previous Name	dedicator of cyto-kinesis 3
Location	3p21
Position	chr3:50675241-51384198, 1
External Links	HGNC: 2989 Entrez Gene: 1795 Ensembl: ENSG00000088538 UCSC: uc011bds.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs9819195	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005085	guanyl-nucleotide exchange factor activity	molecular function	IEA	3

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0043547	positive regulation of GTPase activity	biological process	IEA	30
GO:0007264	small GTPase mediated signal transduction	biological process	IEA	18
GO:0017124	SH3 domain binding	molecular function	IEA	11
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0005515	protein binding	molecular function	IPI[17474147]	563

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
DOCK3	CRK	NO	in vitro;yeast 2-hybrid	10854253
DOCK3	PSEN1	NO	in vitro;yeast 2-hybrid	10854253
DOCK3	PSEN2	NO	in vitro;yeast 2-hybrid	10854253

Related other genetic factors

Gene related SNPs (count: 21)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs9819195	chr3:51336276 - 51336276(1)	intron_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs2241785	chr3:51380704 - 51380704(1)	intron_variant; upstream_gene_variant
rs1370124	chr3:51384757 - 51384757(1)	downstream_gene_variant; upstream_gene_variant
rs2304512	chr3:51388050 - 51388050(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs2217938	chr3:51388243 - 51388243(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs3828395	chr3:51374366 - 51374366(1)	intron_variant
rs10510757	chr3:51372633 - 51372633(1)	intron_variant
rs2306431	chr3:51356026 - 51356026(1)	intron_variant
rs4974096	chr3:51355615 - 51355615(1)	intron_variant
rs12493978	chr3:51352151 - 51352151(1)	intron_variant
rs12487468	chr3:51352139 - 51352139(1)	intron_variant
rs751076	chr3:51339743 - 51339743(1)	intron_variant
rs9829057	chr3:51337739 - 51337739(1)	intron_variant
rs9856134	chr3:51335719 - 51335719(1)	intron_variant
rs4468966	chr3:51334219 - 51334219(1)	intron_variant
rs12489219	chr3:51289020 - 51289020(1)	intron_variant
rs4974112	chr3:51283369 - 51283369(1)	intron_variant
rs1480359	chr3:51276763 - 51276763(1)	intron_variant
rs9878592	chr3:51242934 - 51242934(1)	intron_variant
rs12492615	chr3:51179926 - 51179926(1)	intron_variant
rs4346580	chr3:51179147 - 51179147(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)
3p21	chr3:43600000-54400000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr3:50675241..51384198 View in gBrowse