Gene Report

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Basic Info

Approved Symbol	FGF12
Previous Symbol	FGF12B
Symbol Alias	FHF1
Approved Name	fibroblast growth factor 12
Name Alias	fibroblast growth factor 12B, "fibroblast growth factor homologous factor 1", "myocyte-activating factor", "fibroblast growth factor FGF-12b"
Location	3q28
Position	chr3:192139395-192767764, -1
External Links	HGNC: 3668 Entrez Gene: 2257 Ensembl: ENSG00000114279 UCSC: uc003fsx.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Cichon, S.,2011	SNP: rs779279	No positive signal in this gene was observed for BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007399	nervous system development	biological process	TAS[8790420]	40
GO:0007268	synaptic transmission	biological process	IEA	116
GO:0005634	nucleus	cellular component	IDA[8790420]	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007267	cell-cell signaling	biological process	TAS[10049777]	29
GO:0008543	fibroblast growth factor receptor signaling pathway	biological process	IDA[12815063]; IEA	21
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0008083	growth factor activity	molecular function	IEA	15
GO:0044325	ion channel binding	molecular function	ISS[12401812]	14
GO:0086002	cardiac muscle cell action potential involved in contraction	biological process	NAS[12401812]	1
GO:0005615	extracellular space	cellular component	TAS[10049777]	85
GO:0007165	signal transduction	biological process	TAS[10049777]	136
GO:0010765	positive regulation of sodium ion transport	biological process	IEA	3
GO:1902305	regulation of sodium ion transmembrane transport	biological process	ISS[12401812]	2
GO:0003254	regulation of membrane depolarization	biological process	IEA	1
GO:0008201	heparin binding	molecular function	IDA[12815063]	8
GO:0007254	JNK cascade	biological process	IPI[12815063]	8
GO:0017080	sodium channel regulator activity	molecular function	ISS[12401812]	4
GO:0050905	neuromuscular process	biological process	IEA	3
GO:2001258	negative regulation of cation channel activity	biological process	IEA	2
GO:0005104	fibroblast growth factor receptor binding	molecular function	IDA[12815063]	1
GO:0008344	adult locomotory behavior	biological process	IEA	15
GO:0007507	heart development	biological process	TAS[10049777]	20
GO:2000649	regulation of sodium ion transmembrane transporter activity	biological process	ISS[12401812]	2

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04010	MAPK signaling pathway	39

ID	Name	No. of Genes in BDgene	Brief Description
hsa05218	Melanoma	7
hsa04810	Regulation of actin cytoskeleton	24

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
FGF12	MAPK8IP2	YES	in vivo;yeast 2-hybrid	11378392

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs779279	chr3:191826138 - 191826138(1)		1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr3:192139395..192767764 View in gBrowse