Gene Report

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Basic Info

Approved Symbol	CERS3
Previous Symbol	LASS3
Symbol Alias	MGC27091
Approved Name	ceramide synthase 3
Previous Name	LAG1 longevity assurance homolog 3 (S. cerevisiae), "LAG1 homolog, ceramide synthase 3"
Location	15q26.3
Position	chr15:100400395-100544995, -1
External Links	HGNC: 23752 Entrez Gene: 204219 Ensembl: ENSG00000154227 UCSC: uc002bwb.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Jamain, S., 2014	SNP: rs1393941	It showed nominal evidence for association with BD.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003677	DNA binding	molecular function	IEA	83
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006665	sphingolipid metabolic process	biological process	TAS	6
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0031965	nuclear membrane	cellular component	IEA	15
GO:0005789	endoplasmic reticulum membrane	cellular component	TAS	52
GO:0005783	endoplasmic reticulum	cellular component	IBA	49
GO:0030216	keratinocyte differentiation	biological process	IMP[23754960]	3
GO:0030148	sphingolipid biosynthetic process	biological process	TAS	3
GO:0050291	sphingosine N-acyltransferase activity	molecular function	IBA	1
GO:0046513	ceramide biosynthetic process	biological process	IMP[23754960]	3

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1393941	chr15:100523296 - 100523296(1)	intron_variant; non_coding_transcript_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
15q26.3	chr15:98000000-101991189	1 (0/1/0)
15q25-26	chr15:78000000-101991189	1 (1/0/0)
15q26	chr15:88500000-101991189	1 (0/1/0)
Chr 15	chr15:0-101991189	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr15:100400395..100544995 View in gBrowse