Gene Report

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Basic Info

Approved Symbol	ZXDC
Symbol Alias	MGC11349, FLJ13861
Approved Name	ZXD family zinc finger C
Location	3q21.3
Position	chr3:126437601-126475919, -1
External Links	HGNC: 28160 Entrez Gene: 79364 Ensembl: ENSG00000070476 UCSC: uc003eiv.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Djurovic, S.,2010	SNP: rs10901040	No significant association of this gene was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IEA	283
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IMP[17493635]	66
GO:0003676	nucleic acid binding	molecular function	IEA	5

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0070742	C2H2 zinc finger domain binding	molecular function	IPI[17493635]	2
GO:0045893	positive regulation of transcription, DNA-templated	biological process	IDA[17696781]; IMP[16600381]	58
GO:0005515	protein binding	molecular function	IPI[16600381]	563
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0005575	cellular_component	cellular component	ND	19
GO:0030275	LRR domain binding	molecular function	IPI[16600381]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ZXDC	NR1H2	NO	yeast 2-hybrid	15604093
ZXDC	CIITA	NO	in vivo;yeast 2-hybrid	16600381
ZXDC	RORA	YES	yeast 2-hybrid	15604093

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs10901040	chr7:154638563 - 154638563(1)	intron_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
3q21	chr3:122200000-129500000	1 (0/1/0)
Chr 3	chr3:0-198295559	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr3:126437601..126475919 View in gBrowse