Gene Report

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Basic Info

Approved Symbol	VRK2
Approved Name	vaccinia related kinase 2
Location	2p16.1
Position	chr2:57907651-58159920, 1
External Links	HGNC: 12719 Entrez Gene: 7444 Ensembl: ENSG00000028116 UCSC: uc002rzv.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Steinberg, S.,2012	SNP: rs2312147	No significant association was observed.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0005634	nucleus	cellular component	IDA[16704422]	283
GO:0004674	protein serine/threonine kinase activity	molecular function	IDA[14645249]	27

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005515	protein binding	molecular function	IPI[16963744]	563
GO:2000659	regulation of interleukin-1-mediated signaling pathway	biological process	IMP[18286207]	1
GO:0005524	ATP binding	molecular function	IEA	118
GO:0005737	cytoplasm	cellular component	IDA[16704422]	322
GO:0006897	endocytosis	biological process	IBA	15
GO:0018105	peptidyl-serine phosphorylation	biological process	IBA	11
GO:0006468	protein phosphorylation	biological process	TAS[9344656]	42
GO:0046777	protein autophosphorylation	biological process	IDA[14645249]	16
GO:0031966	mitochondrial membrane	cellular component	IDA[18286207]	3
GO:0034599	cellular response to oxidative stress	biological process	IMP[17709393]	7
GO:0005783	endoplasmic reticulum	cellular component	IDA	49
GO:0043408	regulation of MAPK cascade	biological process	IMP[20679487]	6
GO:0008360	regulation of cell shape	biological process	IBA	16
GO:0016055	Wnt signaling pathway	biological process	IBA	12
GO:0005789	endoplasmic reticulum membrane	cellular component	IDA[18286207]	52
GO:0016032	viral process	biological process	IEA	26

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
VRK2	MAPK8IP1	YES	in vitro;in vivo	18286207
VRK2	MAP3K7	NO	in vitro	18286207
VRK2	MAP2K7	NO	in vitro	18286207

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2312147	chr2:57995793 - 57995793(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs10189138	chr2:57926541 - 57926541(1)	intron_variant; non_coding_transcript_variant	1(1/0/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 7)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2p16.1	chr2:54700000-61000000	1 (0/0/1)
2p16.1-q11.2	chr2:54700000-102100000	1 (1/0/0)
2p16.2-p11.2	chr2:52600000-91800000	1 (1/0/0)
2p13-16	chr2:47500000-71300000	1 (0/0/1)
2p16	chr2:47500000-61000000	1 (0/1/0)
Chr 2	chr2:0-242193529	3 (0/3/0)
2p22.2-p13.3	chr2:36300000-71300000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
23164818	Association results in schizophrenia follow-up samples(10,671 cases; 23,900 controls):OR(95% CI) = 1.07 (1.03, 1.11),P-value = 0.00023. No significant association was observed.	Negative

Gene relationship with MDD

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Region: chr2:57907651..58159920 View in gBrowse