Gene Report

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Basic Info

Approved Symbol	COBL
Symbol Alias	KIAA0633
Approved Name	cordon-bleu WH2 repeat protein
Previous Name	cordon-bleu homolog (mouse)
Location	7p12.2-p12.1
Position	chr7:51016212-51316818, -1
External Links	HGNC: 22199 Entrez Gene: 23242 Ensembl: ENSG00000106078 UCSC: uc003tps.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Chen, X., 2015		COBL has been implicated in SCZ and autism spectrum disorders.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	ISS	360
GO:0016020	membrane	cellular component	ISS	137

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030041	actin filament polymerization	biological process	ISS	4
GO:0030903	notochord development	biological process	ISS	1
GO:0033504	floor plate development	biological process	ISS	1
GO:0005884	actin filament	cellular component	ISS	9
GO:1900029	positive regulation of ruffle assembly	biological process	IEA	1
GO:0044294	dendritic growth cone	cellular component	ISS	1
GO:0030424	axon	cellular component	ISS	39
GO:0001843	neural tube closure	biological process	ISS	8
GO:0043025	neuronal cell body	cellular component	ISS	50
GO:0003785	actin monomer binding	molecular function	ISS	4
GO:0001889	liver development	biological process	ISS	14
GO:0044295	axonal growth cone	cellular component	ISS	2
GO:0001726	ruffle	cellular component	ISS	10
GO:0048565	digestive tract development	biological process	ISS	4
GO:0048669	collateral sprouting in absence of injury	biological process	ISS	1
GO:0051639	actin filament network formation	biological process	ISS	1
GO:0048471	perinuclear region of cytoplasm	cellular component	ISS	50
GO:0005938	cell cortex	cellular component	ISS	7
GO:0001757	somite specification	biological process	ISS	2
GO:1900006	positive regulation of dendrite development	biological process	ISS	2
GO:0000578	embryonic axis specification	biological process	ISS	1
GO:0030425	dendrite	cellular component	ISS	65

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7p11-p13	chr7:43300000-59900000	1 (0/1/0)
Chr 7	chr7:0-159345973	3 (0/3/0)
7p15-q21	chr7:20900000-98400000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr7:51016212..51316818 View in gBrowse