Gene Report

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Basic Info

Approved Symbol	CDH15
Previous Symbol	CDH3, CDH14
Approved Name	cadherin 15, type 1, M-cadherin (myotubule)
Previous Name	cadherin 15, M-cadherin (myotubule)
Location	16q24.3
Position	chr16:89171767-89195492, 1
External Links	HGNC: 1754 Entrez Gene: 1013 Ensembl: ENSG00000129910 UCSC: uc002fmt.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Noor A., 2014		Selected stringent CNV related to this gene is validated by qPCR from BD case data.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0007155	cell adhesion	biological process	TAS[9545347]	42
GO:0005509	calcium ion binding	molecular function	IEA	50
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	biological process	IEA	7
GO:0045216	cell-cell junction organization	biological process	TAS	8
GO:0042692	muscle cell differentiation	biological process	TAS	5
GO:0031594	neuromuscular junction	cellular component	IEA	9
GO:0034332	adherens junction organization	biological process	TAS	6
GO:0051149	positive regulation of muscle cell differentiation	biological process	TAS	2
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23533145]	176
GO:0005901	caveola	cellular component	IEA	11
GO:0034329	cell junction assembly	biological process	TAS	8
GO:0005515	protein binding	molecular function	IPI[25416956]	563

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04514	Cell adhesion molecules (CAMs)	14

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 9)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CDH15	CDON	NO	in vivo	12634428
CDH15	ARVCF	YES	in vitro;in vivo;yeast 2-hybrid	11058098
CDH15	BOC	NO	in vivo	12634428
CDH15	JUP	NO	in vitro	9168809
CDH15	GNA12	YES	in vitro;yeast 2-hybrid	11136230
CDH15	CDH9	NO	in vivo	10861224
CDH15	CTNNA1	NO	in vitro	9168809
CDH15	CTNNB1	NO	in vitro	9545347
CDH15	CDH7	YES	in vivo	10861224

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Abdul Noor[2014]_34	chr16:87762449-87791352 (NCBI Build 36/hg18)	29000	16q24.3	deletion

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 16	chr16:0-90338345	5 (1/3/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr16:89171767..89195492 View in gBrowse