Gene Report

Basic Info
Approved Symbol PI4K2B
Symbol Alias PI4KIIB, FLJ11105, PIK42B
Approved Name phosphatidylinositol 4-kinase type 2 beta
Location 4p15.31
Position chr4:25233975-25279092, 1
External Links HGNC: 18215
Entrez Gene: 55300
Ensembl: ENSG00000038210
UCSC: uc003grk.2
No. of Studies 1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Houlihan, L.M.,2009 Haplotype: rs10939038 - rs3756207(), rs17408391 - rs10939038() Expression studies at the allele-specific mRNA and protein level using lymphoblastoid cell lines from members of the large Scottish family, which showed linkage to 4p15-p16 in bipolar disorder and recurrent major depression, showed no difference in expression differences between affected and non-affected family members.There is no evidence to suggest that PI4K2B is contributing to bipolar disorder in this family but a role for this gene in schizophrenia has not been excluded. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 9)

GO terms by PBA (count: 1)

GO terms by database search (count: 8)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr4:25233975..25279092 View in gBrowse
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