Gene Report

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Basic Info

Approved Symbol	PI4K2B
Symbol Alias	PI4KIIB, FLJ11105, PIK42B
Approved Name	phosphatidylinositol 4-kinase type 2 beta
Location	4p15.31
Position	chr4:25233975-25279092, 1
External Links	HGNC: 18215 Entrez Gene: 55300 Ensembl: ENSG00000038210 UCSC: uc003grk.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Houlihan, L.M.,2009	Haplotype: rs10939038 - rs3756207(), rs17408391 - rs10939038()	Expression studies at the allele-specific mRNA and protein level using lymphoblastoid cell lines from members of the large Scottish family, which showed linkage to 4p15-p16 in bipolar disorder and recurrent major depression, showed no difference in expression differences between affected and non-affected family members.There is no evidence to suggest that PI4K2B is contributing to bipolar disorder in this family but a role for this gene in schizophrenia has not been excluded.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016020	membrane	cellular component	IDA[19946888]	137

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0005829	cytosol	cellular component	TAS	223
GO:0046854	phosphatidylinositol phosphorylation	biological process	IEA	10
GO:0005524	ATP binding	molecular function	IEA	118
GO:0006644	phospholipid metabolic process	biological process	TAS	18
GO:0004430	1-phosphatidylinositol 4-kinase activity	molecular function	IEA	2
GO:0006661	phosphatidylinositol biosynthetic process	biological process	TAS	13

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PI4K2B	CD247	NO	in vitro;in vivo	16337488
PI4K2B	CASR	NO	in vivo	11907035

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 4	chr4:0-190214555	3 (0/3/0)
4p14-p15	chr4:11300000-41200000	1 (0/1/0)
4p	chr4:0-50000000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19539307	There is no evidence to suggest that PI4K2B is contributing to bipolar disorder in this family but a role for this gene in schizophrenia has not been excluded.	Positive

Reference	ID in SZGene	Result Category
19539307	843	Positive

Gene relationship with MDD

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Region: chr4:25233975..25279092 View in gBrowse